The T-cell receptor (TCR) functions in both antigen recognition and signal transduction,
which are crucial initial steps of antigen-specific immune responses. TCR integrity is vital for …

Impaired balance between mature and immature myeloid cells is one of the hallmarks of
cancer. In cancer patients as well as in mouse models there is increasing evidence that …

Tumor growth is associated with the accumulation of immature myeloid cells (ImC), which in
mice are characterized by the expression of Gr-1 and CD11b markers. These cells suppress …

Abstract CD11b+ Gr-1+ myeloid suppressor cells (MSC) accumulate in lymphoid organs
under conditions of intense immune stress where they inhibit T and B cell function. We …

Purpose Phenotypic and functional features of myeloid suppressor cells (MSC), which are
known to serve as critical regulators of antitumor T-cell responses in tumor-bearing mice, are …

Apoptotic death of CD8+ T cells can be induced by a population of inhibitory myeloid cells
that are double positive for the CD11b and Gr-1 markers. These cells are responsible for the …

Tumor-induced immunosuppression is one of the crucial mechanisms of tumor evasion of
immune surveillance. It contributes greatly to the failure of cancer vaccines. Immature …

Tumor cells gene-modified to produce GM-CSF potently stimulate antitumor immune
responses, in part, by causing the growth and differentiation of dendritic cells (DC) …

Following an infection or immunization, a primary CD8+ T cell response generally rises then
falls rapidly before giving rise to a “memory” response. When we immunized mice with …

It is well established that tumor growth is associated with accumulation of immature myeloid
cells (ImC). They play an important role in tumor-associated immune suppression. ImC …