Forming functional fat: a growing understanding of adipocyte differentiation

AG Cristancho, MA Lazar - Nature reviews Molecular cell biology, 2011 - nature.com
Adipose tissue, which is primarily composed of adipocytes, is crucial for maintaining energy
and metabolic homeostasis. Adipogenesis is thought to occur in two stages: commitment of …

Dietary factors, epigenetic modifications and obesity outcomes: progresses and perspectives

FI Milagro, ML Mansego, C De Miguel… - Molecular aspects of …, 2013 - Elsevier
Nutritional factors play a life-long role in human health. Indeed, there is growing evidence
that one of the mechanisms by which nutrients and bioactive compounds affect metabolic …

A large multiethnic genome-wide association study of adult body mass index identifies novel loci

TJ Hoffmann, H Choquet, J Yin, Y Banda, MN Kvale… - Genetics, 2018 - academic.oup.com
Body mass index (BMI), a proxy measure for obesity, is determined by both environmental
(including ethnicity, age, and sex) and genetic factors, with> 400 BMI-associated loci …

The beige adipocyte as a therapy for metabolic diseases

F Lizcano - International journal of molecular sciences, 2019 - mdpi.com
Adipose tissue is traditionally categorized into white and brown relating to their function and
morphology. The classical white adipose tissue builds up energy in the form of triglycerides …

H3K36 trimethylation mediated by SETD2 regulates the fate of bone marrow mesenchymal stem cells

L Wang, N Niu, L Li, R Shao, H Ouyang, W Zou - PLoS biology, 2018 - journals.plos.org
During the aging process, bone marrow mesenchymal stem cells (BMSCs) exhibit declined
osteogenesis accompanied by excess adipogenesis, which will lead to osteoporosis. Here …

The PPARα and PPARγ epigenetic landscape in cancer and immune and metabolic disorders

J Porcuna, J Mínguez-Martínez, M Ricote - International journal of …, 2021 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs) are ligand-modulated nuclear
receptors that play pivotal roles in nutrient sensing, metabolism, and lipid-related processes …

Epigenetic regulation of adipogenesis in development of metabolic syndrome

R Pant, P Firmal, VK Shah, A Alam… - Frontiers in Cell and …, 2021 - frontiersin.org
Obesity is one of the biggest public health concerns identified by an increase in adipose
tissue mass as a result of adipocyte hypertrophy and hyperplasia. Pertaining to the …

An integrative framework to prioritize genes in more than 500 loci associated with body mass index

D Hemerich, V Svenstrup, VD Obrero, M Preuss… - The American Journal of …, 2024 - cell.com
Obesity is a major risk factor for a myriad of diseases, affecting> 600 million people
worldwide. Genome-wide association studies (GWASs) have identified hundreds of genetic …

Static mechanical stretching accelerates lipid production in 3T3-L1 adipocytes by activating the MEK signaling pathway

N Shoham, R Gottlieb… - … of Physiology-Cell …, 2012 - journals.physiology.org
Understanding mechanotransduction in adipocytes is important for research of obesity and
related diseases. We cultured 3T3-L1 preadipocytes on elastic substrata and applied static …

Control of adipose cell browning and its therapeutic potential

F Lizcano, F Arroyave - Metabolites, 2020 - mdpi.com
Adipose tissue is the largest endocrine organ in humans and has an important influence on
many physiological processes throughout life. An increasing number of studies have …