ABSTRACT A vast array of oncogenic variants has been identified for anaplastic lymphoma
kinase (ALK). Therefore, there is a need to better understand the role of ALK in cancer …

The burgeoning field of anaplastic lymphoma kinase (ALK) in cancer encompasses many
cancer types, from very rare cancers to the more prevalent non-small-cell lung cancer …

RTKs (receptor tyrosine kinases) play important roles in cellular proliferation and
differentiation. In addition, RTKs reveal oncogenic potential when their kinase activities are …

Peripheral T cell lymphomas (PTCLs) are a heterogeneous group of orphan neoplasms.
Despite the introduction of anthracycline-based chemotherapy protocols, with or without …

Introduction: Rho GTPases are master regulators of actomyosin structure and dynamics and
play pivotal roles in a variety of cellular processes including cell morphology, gene …

[Frontiers in Bioscience 16, 2561-2571, June 1, 2011] Role of Rho GTPases and their regulators
in cancer progression Rajamani R Page 1 [Frontiers in Bioscience 16, 2561-2571, June 1 …

The Vav family is a group of tyrosine phosphorylation-regulated signal transduction
molecules hierarchically located downstream of protein tyrosine kinases. The main function …

Peripheral T-cell lymphomas (PTCLs) represent a heterogeneous group of T-cell
malignancies that generally demonstrate aggressive clinical behavior, often are refractory to …

Small GTPases are a family of low molecular weight GTP-hydrolyzing enzymes that cycle
between an inactive state when bound to GDP and an active state when associated to GTP …

Although genetics determines endocrine phenotypes, it cannot fully explain the great
variability and reversibility of the system in response to environmental changes. Evidence …