Interleukin-1 (IL-1) is a primary cytokine of innate immunity and inflammation. IL-1 belongs to
a complex family including ligands with agonist activity, receptor antagonists, and an anti …

Interleukin‐1 receptor family members (ILR s) and Toll‐Like Receptors (TLR s) are key
players in immunity and inflammation and are tightly regulated at different levels. Most cell …

Here, we describe the development of WikiPathways (http://www. wikipathways. org), a
public wiki for pathway curation, since it was first published in 2008. New features are …

Necrosis can induce profound inflammation or be clinically silent. However, the mechanisms
underlying such tissue specificity are unknown. Interleukin-1α (IL-1α) is a key danger signal …

Background Pancreatic ductal adenocarcinoma (PDAC) is known by its aggressiveness and
lack of effective therapeutic options. Thus, improvement in current knowledge of molecular …

The IL-1 family of ligands and receptors has a central role in both innate and adaptive
immune responses and is tightly controlled by antagonists, decoy receptors, scavengers …

Interleukin-1 receptor type 2 (IL1R2) acts as a decoy receptor of exogenous IL-1; however,
its intracellular activity is poorly understood. We previously demonstrated that IL1R2 …

Development of head and neck squamous cell carcinoma (HNSCC) is characterized by
accumulation of mutations in several oncogenes and tumor suppressor genes. We have …

Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human cancers.
Transforming Growth Factor Beta (TGF-β) is a cytokine that switches from a tumor …

Members of the IL-1 family play a key role in innate and adaptive immunity and in the
pathogenesis of diverse diseases. Members of IL-1R like receptor (ILR) family include …