Fluorine-containing amino acids are becoming increasingly prominent in new drugs due to
two general trends in the modern pharmaceutical industry. Firstly, the growing acceptance of …

Structural analysis of modern pharmaceutical practices allows for the identification of two
rapidly growing trends: the introduction of tailor‐made amino acids and the exploitation of …

The conversion of C‒H bonds to C‒N bonds offers a sustainable and economical strategy
for the synthesis of nitrogen-containing compounds. However, challenges regarding the …

Unnatural chiral α-tertiary amino acids containing two different carbon-based substituents at
the α-carbon centre are widespread in biologically active molecules. This sterically rigid …

We report a stereoselective and site-specific allylic alkylation of Schiff base activated amino
acids and small peptides via a Pd/Cu dual catalysis. A range of noncoded α, α-dialkyl α …

Enantioenriched α‐tertiary‐α‐aminoacid and α‐chiral‐β‐aminoacid derivatives play an
important role in biological science and pharmaceutical chemistry. Thus, the development of …

Biosynthesis utilizes kinetic strategies to regulate the chemoselectivity for the
transformations of molecules containing multiple active reaction sites. But it is a grand …

A highly efficient synthetic approach to unnatural chiral β-Ar, Ar′-α-amino acid esters
bearing two contiguous stereogenic centers has been developed. The first enantioselective …

The synthesis of unnatural, tertiary amino acids is a challenging task. While decarboxylation–
radical addition has been an important strategy for their formation, the use of alkyl radicals …

Tailor-made AAs are indispensable components of modern medicinal chemistry and are
becoming increasingly prominent in new drugs. In fact, about 30% of small-molecule …