Sex‐specific aging in animals: perspective and future directions

AM Bronikowski, RP Meisel, PR Biga, JR Walters… - Aging …, 2022 - Wiley Online Library
Sex differences in aging occur in many animal species, and they include sex differences in
lifespan, in the onset and progression of age‐associated decline, and in physiological and …

Cancer risk across mammals

O Vincze, F Colchero, JF Lemaître, DA Conde… - Nature, 2022 - nature.com
Cancer is a ubiquitous disease of metazoans, predicted to disproportionately affect larger,
long-lived organisms owing to their greater number of cell divisions, and thus increased …

Sex differences in adult lifespan and aging rates of mortality across wild mammals

JF Lemaître, V Ronget, M Tidière… - Proceedings of the …, 2020 - National Acad Sciences
In human populations, women consistently outlive men, which suggests profound biological
foundations for sex differences in survival. Quantifying whether such sex differences are also …

Diverse aging rates in ectothermic tetrapods provide insights for the evolution of aging and longevity

BA Reinke, H Cayuela, FJ Janzen, JF Lemaître… - Science, 2022 - science.org
Comparative studies of mortality in the wild are necessary to understand the evolution of
aging; yet, ectothermic tetrapods are underrepresented in this comparative landscape …

An integrative view of senescence in nature

JM Gaillard, JF Lemaître - Functional Ecology, 2020 - Wiley Online Library
Senescence—the decline in age‐specific contribution to fitness with increasing age—has
been widely investigated in evolutionary ecology. A tremendous amount of detailed …

The evolution of menopause in toothed whales

S Ellis, DW Franks, MLK Nielsen, MN Weiss, DP Croft - Nature, 2024 - nature.com
Understanding how and why menopause has evolved is a long-standing challenge across
disciplines. Females can typically maximize their reproductive success by reproducing for …

DNA methylation as a tool to explore ageing in wild roe deer populations

J Lemaître, B Rey, J Gaillard, C Régis… - Molecular ecology …, 2022 - Wiley Online Library
DNA methylation‐based biomarkers of ageing (epigenetic clocks) promise to lead to new
insights into evolutionary biology of ageing. Relatively little is known about how the natural …

Epigenetic predictors of species maximum life span and other life-history traits in mammals

CZ Li, A Haghani, Q Yan, AT Lu, J Zhang, Z Fei… - Science …, 2024 - science.org
By analyzing 15,000 samples from 348 mammalian species, we derive DNA methylation
(DNAm) predictors of maximum life span (R= 0.89), gestation time (R= 0.96), and age at …

Female reproductive senescence across mammals: a high diversity of patterns modulated by life history and mating traits

JF Lemaître, V Ronget, JM Gaillard - Mechanisms of Ageing and …, 2020 - Elsevier
Senescence patterns are highly variable across the animal kingdom. However, while
empirical evidence of actuarial senescence in vertebrates is accumulating in the wild and …

Genomic signatures of thermal adaptation are associated with clinal shifts of life history in a broadly distributed frog

H Cayuela, Y Dorant, BR Forester… - Journal of Animal …, 2022 - Wiley Online Library
Temperature is a critical driver of ectotherm life‐history strategies, whereby a warmer
environment is associated with increased growth, reduced longevity and accelerated …