Phenolic compounds that cross the blood–brain barrier exert positive health effects as central nervous system antioxidants
D Velásquez-Jiménez, DA Corella-Salazar… - Food & Function, 2021 - pubs.rsc.org
The blood–brain barrier (BBB) is a physical structure whose main function is to strictly
regulate access to circulating compounds into the central nervous system (CNS). Vegetable …
regulate access to circulating compounds into the central nervous system (CNS). Vegetable …
[HTML][HTML] Oxidative stress at the crossroads of aging, stroke and depression
Epidemiologic studies have shown that in the aging society, a person dies from stroke every
3 minutes and 42 seconds, and vast numbers of people experience depression around the …
3 minutes and 42 seconds, and vast numbers of people experience depression around the …
Naringenin protects AlCl3/D-galactose induced neurotoxicity in rat model of AD via attenuation of acetylcholinesterase levels and inhibition of oxidative stress
Currently prescribed medications for the treatment of Alzheimer's disease (AD) that are
based on acetylcholinesterase inhibition only offer symptomatic relief but do not provide …
based on acetylcholinesterase inhibition only offer symptomatic relief but do not provide …
Naringenin improves depressive-and anxiety-like behaviors in mice exposed to repeated hypoxic stress through modulation of oxido-inflammatory mediators and NF …
Oxidative and inflammatory signaling pathways have been identified as important targets for
mitigating hypoxic stress-induced neurological complications. Thus, the effects of …
mitigating hypoxic stress-induced neurological complications. Thus, the effects of …
[HTML][HTML] Polyphenols as novel interventions for depression: exploring the efficacy, mechanisms of action, and implications for future research
Numerous animal and human studies have assessed the relationship between polyphenols
and outcomes related to depression. However, no comprehensive synthesis of the main …
and outcomes related to depression. However, no comprehensive synthesis of the main …
Normalization of HPA axis, cholinergic neurotransmission, and inhibiting brain oxidative and inflammatory dynamics are associated with the adaptogenic-like effect of …
JOT Emudainohwo, B Ben-Azu, OG Adebayo… - Journal of Molecular …, 2023 - Springer
Social defeat stress (SDS) due to changes in biochemical functions has been implicated in
the pathogenesis of affective and cognitive disorders. Employing pharmacological approach …
the pathogenesis of affective and cognitive disorders. Employing pharmacological approach …
[HTML][HTML] Possible neuroprotective mechanisms of action involved in the neurobehavioral property of naringin in mice
B Ben-Azu, EE Nwoke, AO Aderibigbe… - Biomedicine & …, 2019 - Elsevier
Flavonoids are naturally occurring bioactive phytochemical metabolites widely known to
prevent and suppress several human diseases, and are important sources of therapeutic …
prevent and suppress several human diseases, and are important sources of therapeutic …
Oxidation-reduction mechanisms in psychiatric disorders: A novel target for pharmacological intervention
AC Rossetti, MS Paladini, MA Riva, R Molteni - Pharmacology & …, 2020 - Elsevier
While neurotransmitter dysfunction represents a key component in mental illnesses, there is
now a wide agreement for a central pathophysiological hub that includes hormones …
now a wide agreement for a central pathophysiological hub that includes hormones …
Neurobiological mechanisms of mood disorders: Stress vulnerability and resilience
C Marcolongo-Pereira, FCAQ Castro… - Frontiers in behavioral …, 2022 - frontiersin.org
Stress is an important factor in the development of several human pathologies. The
response of rodents and humans to stress depends on many factors; some people and …
response of rodents and humans to stress depends on many factors; some people and …
Naringin confers protection against psychosocial defeat stress-induced neurobehavioral deficits in mice: involvement of glutamic acid decarboxylase isoform-67, oxido …
Psychosocial stress has been widely reported to contribute to psychiatric disturbances.
Perturbations in the enzymes of GABAergic and cholinergic systems have been implicated …
Perturbations in the enzymes of GABAergic and cholinergic systems have been implicated …