Nuclear bodies (NBs) are biomolecular condensates that participate in various cellular
processes and respond to cellular stimuli in the nucleus. The assembly and function of these …

In recent years, it has become increasingly clear that many nuclear membrane-less
compartments have liquid-like properties and may form through the physicochemical …

Dynamic imaging of genomic loci is key for understanding gene regulation, but methods for
imaging genomes, in particular non-repetitive DNAs, are limited. We developed …

Recent advances in single-molecule imaging of mRNAs in fixed and living cells have
enabled the lives of mRNAs to be studied with unprecedented spatial and temporal detail …

The mammalian nucleus is compartmentalized by diverse subnuclear structures. These
subnuclear structures, marked by nuclear bodies and histone modifications, are often cell …

Biomolecular condensates, sometimes also known as membraneless organelles (MLOs),
can form through weak multivalent intermolecular interactions of proteins and nucleic acids …

The carboxy-terminus of the spliceosomal protein PRPF8, which regulates the RNA helicase
Brr2, is a hotspot for mutations causing retinitis pigmentosa-type 13, with unclear role in …

Expansion of an intronic (GGGGCC) n repeat within the C9ORF72 gene is the most common
genetic cause of both frontotemporal dementia (FTD) and amyotrophic lateral sclerosis …

CircRNAs are an important class of RNAs with diverse cellular functions in human
physiology and disease. A thorough knowledge of circRNAs including their biogenesis and …

Nuclear speckles, also known as interchromatin granule clusters (IGCs), are subnuclear
domains highly enriched in proteins involved in transcription and mRNA metabolism and …