[HTML][HTML] Cell penetrating peptides: A concise review with emphasis on biomedical applications

H Derakhshankhah, S Jafari - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Introduction The biological membranes as natural permeable barriers are required for
survival and function of living cells. However, these natural barriers could be a major …

Delivery of bioactive molecules into the cell: the Trojan horse approach

GPH Dietz, M Bähr - Molecular and Cellular Neuroscience, 2004 - Elsevier
In recent years, vast amounts of data on the mechanisms of neural de-and regeneration
have accumulated. However, only in disproportionally few cases has this led to efficient …

Arginine-rich molecular transporters for drug delivery: role of backbone spacing in cellular uptake

JB Rothbard, E Kreider, CL VanDeusen… - Journal of medicinal …, 2002 - ACS Publications
Short oligomers of arginine, either alone or when conjugated to therapeutic agents or large
biopolymers, have been shown to cross readily a variety of biological barriers (eg, lipid …

[HTML][HTML] Cargo delivery kinetics of cell-penetrating peptides

M Hällbrink, A Florén, A Elmquist, M Pooga… - … et Biophysica Acta (BBA …, 2001 - Elsevier
A diversity of cell-penetrating peptides (CPPs), is known, but so far the only common
denominator for these peptides is the ability to gain cell entry in an energy-independent …

Break on through to the other side—biophysics and cell biology shed light on cell‐penetrating peptides

R Fischer, M Fotin‐Mleczek, H Hufnagel… - …, 2005 - Wiley Online Library
Cell‐penetrating peptides (CPPs) have become widely used vectors for the cellular import of
molecules in basic and applied biomedical research. Despite the broad acceptance of these …

A brief introduction to cell‐penetrating peptides

P Lundberg, Ü Langel - Journal of Molecular Recognition, 2003 - Wiley Online Library
Cell membranes act as protective walls to exclude most molecules that are not actively
imported by living cells. This is an efficient way for a cell to prevent uncontrolled influx or …

Insight into the mechanism of internalization of the cell-penetrating carrier peptide Pep-1 through conformational analysis

S Deshayes, A Heitz, MC Morris, P Charnet… - Biochemistry, 2004 - ACS Publications
Recently, we described a new strategy for the delivery of proteins and peptides into
mammalian cells, based on an amphipathic peptide of 21 residues, Pep-1, which was …

Interactions of phospholipid-and poly (ethylene glycol)-modified surfaces with biological systems: relation to physico-chemical properties and mechanisms

P Vermette, L Meagher - Colloids and Surfaces B: Biointerfaces, 2003 - Elsevier
This paper critically reviews reports on the interactions of phospholipids and poly (ethylene
glycol)(PEG)—also called poly (ethylene oxide)(PEO)—with biological systems (model …

Membrane binding and translocation of cell-penetrating peptides

PEG Thorén, D Persson, EK Esbjörner, M Goksör… - Biochemistry, 2004 - ACS Publications
Cell-penetrating peptides (CPPs) have been extensively studied during the past decade,
because of their ability to promote the cellular uptake of various cargo molecules, eg …

[HTML][HTML] Alternative mechanisms for the interaction of the cell-penetrating peptides penetratin and the TAT peptide with lipid bilayers

S Yesylevskyy, SJ Marrink, AE Mark - Biophysical journal, 2009 - cell.com
Cell-penetrating peptides (CPPs) have recently attracted much interest due to their apparent
ability to penetrate cell membranes in an energy-independent manner. Here molecular …