Heparin has been used extensively as an antithrombotic and anticoagulant for close to 100
years. This anticoagulant activity is attributed mainly to the pentasaccharide sequence …

Vascular hyperpermeability is a frequent intractable feature involved in a wide range of
diseases in the intensive care unit. The glycocalyx (GCX) seemingly plays a key role to …

Objective: The endothelial glycocalyx (eGC) is a dynamic and multicomponent layer of
macromolecules found at the surface of vascular endothelium, which is largely …

Graft rejection remains the major obstacle after vascularized solid organ transplantation.
Endothelial cells, which form the interface between the transplanted graft and the host's …

Background Increased vascular permeability is a pathophysiological hallmark of sepsis and
results in increased transcapillary leakage of plasma fluid, hypovolemia, and interstitial …

The endothelial surface layer (ESL) consists of the endothelial cell (EC) glycocalyx and
adsorbed proteins, and forms a barrier between blood and the EC. Enzymatic shedding of …

Leukocyte (WBC) to endothelial cell (EC) adhesion is a receptor-mediated process
governed by the avidity and affinity of selectins, which modulate adhesive forces during …

Background Vascular leakage is a common complication of hemorrhagic shock. Endothelial
glycocalyx plays a crucial role in the protection of vascular endothelial barrier function …

Despite the fact that a significant fraction of kidney graft dysfunctions observed after
transplantation is due to ischemia‐reperfusion injuries, there is still no clear consensus …

Ischemia reperfusion injury is one of the major complications responsible for delayed graft
function in kidney transplantation. Applications to reduce reperfusion injury are essential …