Outer membrane vesicle vaccines

F Micoli, CA MacLennan - Seminars in immunology, 2020 - Elsevier
Abstract Outer Membrane Vesicles (OMV) have received increased attention in recent years
as a vaccine platform against bacterial pathogens. OMV from Neisseria meningitidis …

Bacterial outer membrane vesicles as potential biological nanomaterials for antibacterial therapy

W Huang, L Meng, Y Chen, Z Dong, Q Peng - Acta biomaterialia, 2022 - Elsevier
Antibiotic therapy is one of the most important approaches against bacterial infections.
However, the improper use of antibiotics and the emergence of drug resistance have …

An intranasal OMV-based vaccine induces high mucosal and systemic protecting immunity against a SARS-CoV-2 infection

PA van der Ley, A Zariri, E van Riet… - Frontiers in …, 2021 - frontiersin.org
The development of more effective, accessible, and easy to administer COVID-19 vaccines
next to the currently marketed mRNA, viral vector, and whole inactivated virus vaccines is …

Outer membrane vesicles (OMVs) produced by gram‐negative bacteria: structure, functions, biogenesis, and vaccine application

N Furuyama, MP Sircili - BioMed Research International, 2021 - Wiley Online Library
Gram‐negative bacteria produce outer membrane vesicles (OMVs) with 10 to 300 nm of
diameter. The contribution of OMVs to bacterial pathogenesis is a topic of great interest, and …

Alternative biological sources for extracellular vesicles production and purification strategies for process scale-up

S Giancaterino, C Boi - Biotechnology Advances, 2023 - Elsevier
Extracellular vesicles (EVs) are phospholipidic bi-layer enclosed nanoparticles secreted
naturally by all cell types. They are attracting increasing attention in the fields of …

Bacterial membrane vesicle functions, laboratory methods, and applications

PA Çelik, B Derkuş, K Erdoğan, D Barut… - Biotechnology …, 2022 - Elsevier
Bacterial membrane vesicles (BMVs) are cupped-shaped structures formed by bacteria in
response to environmental stress, genetic alteration, antibiotic exposure, and others. Due to …

[HTML][HTML] Bacterial extracellular vesicle applications in cancer immunotherapy

K Suri, A D'Souza, D Huang, A Bhavsar, M Amiji - Bioactive Materials, 2023 - Elsevier
Cancer therapy is undergoing a paradigm shift toward immunotherapy focusing on various
approaches to activate the host immune system. As research to identify appropriate immune …

Bacterial outer membrane vesicles as a versatile tool in vaccine research and the fight against antimicrobial resistance

Z Zhu, F Antenucci, KR Villumsen, AM Bojesen - MBio, 2021 - Am Soc Microbiol
Gram-negative bacteria include a number of pathogens that cause disease in humans and
animals. Although antibiotics are still effective in treating a considerable range of infections …

Outer membrane vesicles: An emerging vaccine platform

D Kashyap, M Panda, B Baral, N Varshney, V Bhandari… - Vaccines, 2022 - mdpi.com
Vaccine adjuvants are substances that improve the immune capacity of a recombinant
vaccine to a great extent and have been in use since the early 1900s; they are primarily …

Outer membrane vesicle vaccine platforms

F Micoli, R Adamo, U Nakakana - BioDrugs, 2024 - Springer
Outer membrane vesicles (OMVs) are spontaneously released by many gram-negative
bacteria during their growth and constitute an important virulence factor for bacteria, helping …