The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

The developmental mechanisms that control body size and the relative sizes of body parts
are today best understood in insects. Size is controlled by the mechanisms that cause …

By the onset of morphogenesis, Drosophila embryos consist of about 6000 cells that express
distinct gene combinations. Here, we used single-cell sequencing of precisely staged …

Animal transcriptomes are dynamic, with each cell type, tissue and organ system expressing
an ensemble of transcript isoforms that give rise to substantial diversity. Here we have …

Drosophila melanogaster is one of the most well studied genetic model organisms;
nonetheless, its genome still contains unannotated coding and non-coding genes …

Chromatin is composed of DNA and a variety of modified histones and non-histone proteins,
which have an impact on cell differentiation, gene regulation and other key cellular …

Determining the composition of protein complexes is an essential step toward
understanding the cell as an integrated system. Using coaffinity purification coupled to mass …

Advances in CRISPR technology have immensely improved our ability to manipulate nucleic
acids, and the recent discovery of the RNA-targeting endonuclease Cas13 adds even further …

We previously reported a CRISPR-mediated knock-in strategy into introns of Drosophila
genes, generating an attP-FRT-SA-T2A-GAL4-polyA-3XP3-EGFP-FRT-attP transgenic …

This report of independent genome sequences of two natural populations of Drosophila
melanogaster (37 from North America and 6 from Africa) provides unique insight into forces …