Abstract Alzheimer's disease (AD), the most common neurodegenerative disorder, is
characterized by memory loss and cognitive dysfunction. The accumulation of misfolded …

Autophagy and endocytosis deliver unneeded cellular materials to lysosomes for
degradation. Beyond processing cellular waste, lysosomes release metabolites and ions …

Alzheimer's disease (AD) is one of the biggest human health threats due to increases in
aging of the global population. Unfortunately, drugs for treating AD have been largely …

Abstract β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the β-secretase
enzyme required for the production of the neurotoxic β-amyloid (Aβ) peptide that is widely …

Summary Presenilin 1 (PS1) deletion or Alzheimer's disease (AD)-linked mutations disrupt
lysosomal acidification and proteolysis, which inhibits autophagy. Here, we establish that …

Microglial activation has been considered a crucial player in the pathological process of
multiple human neurodegenerative diseases. In some of these pathologies, such as …

Alzheimer's disease (AD) constitutes the most prominent form of dementia among elderly
individuals worldwide. Disease modeling using murine transgenic mice was first initiated …

Autophagy is a lysosomal degradative process which recycles cellular waste and eliminates
potentially toxic damaged organelles and protein aggregates. The important cytoprotective …

Accumulation and aggregation of amyloid-β (Aβ) peptides in the brain trigger the
development of progressive neurodegeneration and dementia associated with Alzheimer's …

Reactive astrogliosis, a complex process characterized by cell hypertrophy and upregulation
of components of intermediate filaments, is a common feature in brains of Alzheimer's …