The amino acid sequence of a protein affects both its structure and its function. Thus, the
ability to modify the sequence, and hence the structure and activity, of individual proteins in …

Natural selection drives evolving populations up the fitness landscape, the projection from
nucleotide sequence space to organismal reproductive success. While it has long been …

The structure of fitness landscapes is critical for understanding adaptive protein evolution.
Previous empirical studies on fitness landscapes were confined to either the neighborhood …

Evolutionary game theory is a successful mathematical framework geared towards
understanding the selective pressures that affect the evolution of the strategies of agents …

High-order epistasis has been observed in many genotype-phenotype maps. These multi-
way interactions between mutations may be useful for dissecting complex traits and could …

Zero-determinant strategies are a new class of probabilistic and conditional strategies that
are able to unilaterally set the expected payoff of an opponent in iterated plays of the …

Genome duplication, which results in polyploidy, is disruptive to fundamental biological
processes. Genome duplications occur spontaneously in a range of taxa and problems such …

Breeding for climate resilience is currently an important goal for sustainable livestock
production. Local adaptations exhibited by indigenous livestock allow investigating the …

Fitness landscapes of drug resistance constitute powerful tools to elucidate mutational
pathways of antibiotic escape. Here, we developed a predictive biophysics-based fitness …

Dispersal is a key determinant of a population's evolutionary potential. It facilitates the
propagation of beneficial alleles throughout the distributional range of spatially outspread …