Myosin II is a molecular motor that converts chemical energy derived from ATP hydrolysis
into mechanical work. Myosin II isoforms are responsible for muscle contraction and a range …

Two groundbreaking papers published in 1954 laid out the theory of the mechanism of
muscle contraction based on force-generating interactions between myofilaments in the …

2'-deoxy-ATP (dATP) improves cardiac function by increasing the rate of crossbridge cycling
and Ca 2+ transient decay. However, the mechanisms of these effects and how therapeutic …

Brownian dynamics (BD) is a computational method to simulate molecular diffusion
processes. Although the BD method has been developed over several decades and is well …

Hallmark features of systolic heart failure are reduced contractility and impaired metabolic
flexibility of the myocardium. Cardiomyocytes (CMs) with elevated deoxy ATP (dATP) via …

The understanding of cardiac function and its role in heart diseases can be significantly
advanced through computational modeling of the heart muscle at molecular and …

Pulmonary arterial hypertension (PAH) is a rare, yet aggressive disease with a 3-year
survival rate of 54.9% for humans [6]. This life-threatening disease is characterized by …

Heart failure is a major healthcare challenge, and most existing treatments mitigate its
symptoms without addressing underlying mechanical dysfunction. Therefore, recent …

At the sarcomeric level, McCabe et al.[1] developed a multiscale model to explore the
mechanistic effects of 2'-deoxy-ATP (dATP), an inotrope with therapeutic potential, on the …

Executive summary Familial CardioMyopathies (FCM), in particular Hypertrophic and
Dilated CardioMyopathies (HCM and DCM), are considered diseases of the sarcomere …