Variants of SARS-CoV-2: Influences on the vaccines' effectiveness and possible strategies to overcome their consequences

AA Rabaan, SH Al-Ahmed, H Albayat, S Alwarthan… - Medicina, 2023 - mdpi.com
The immune response elicited by the current COVID-19 vaccinations declines with time,
especially among the immunocompromised population. Furthermore, the emergence of …

Add fuel to the fire: Inflammation and immune response in lung cancer combined with COVID-19

Y Ai, H Wang, Q Zheng, S Li, J Liu, J Huang… - Frontiers in …, 2023 - frontiersin.org
The corona virus disease 2019 (COVID-19) global pandemic has had an unprecedented
and persistent impact on oncological practice, especially for patients with lung cancer, who …

Prenol, but not vitamin C, of fruit binds to SARS-CoV-2 spike S1 to inhibit viral entry: Implications for COVID-19

RK Paidi, M Jana, S Raha, RK Mishra… - The Journal of …, 2023 - journals.aai.org
Fruit consumption may be beneficial for fighting infection. Although vitamin C is the celebrity
component of fruit, its role in COVID-19 is unclear. Because spike S1 of SARS-CoV-2 binds …

Persistence of SARS-CoV-2 IgG antibody response among South African adults: a prospective cohort study

OV Adeniyi, OC Durojaiye, C Masilela - Vaccines, 2023 - mdpi.com
This study assesses the durability of severe acute respiratory coronavirus-2 (SARS-CoV-2)
anti-nucleocapsid (anti-N) immunoglobulin G (IgG) after infection and examines its …

A glimpse into viral warfare: decoding the intriguing role of highly pathogenic coronavirus proteins in apoptosis regulation

L Cheng, Y Rui, Y Wang, S Chen, J Su… - Journal of Biomedical …, 2024 - Springer
Coronaviruses employ various strategies for survival, among which the activation of
endogenous or exogenous apoptosis stands out, with viral proteins playing a pivotal role …

Back to the Basics: Usefulness of Naturally Aged Mouse Models and Immunohistochemical and Quantitative Morphologic Methods in Studying Mechanisms of Lung …

G Jaramillo-Rangel, ML Chávez-Briones… - Biomedicines, 2023 - mdpi.com
Aging-related molecular and cellular alterations in the lung contribute to an increased
susceptibility of the elderly to devastating diseases. Although the study of the aging process …

Rational design of polymer-based mRNA delivery systems for cancer treatment

Q Wan, Y Sun, X Sun, Z Zhou - Polymer Chemistry, 2024 - pubs.rsc.org
Messenger RNA (mRNA)-based cancer therapeutics have shown great promise in cancer
prevention and treatment, such as mRNA cancer vaccines and protein replacement …

Neutralization of p40 Homodimer and p40 Monomer Leads to Tumor Regression in Patient-Derived Xenograft Mice with Pancreatic Cancer

M Sheinin, S Mondal, K Pahan - Cancers, 2023 - mdpi.com
Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest
cancers, and immunotherapy could be one of the safest options to control PDAC. Although …

Intratumor injection of BCG Ag85A high-affinity peptides enhanced anti-tumor efficacy in PPD-positive melanoma

L Qin, G Zhang, Y Wu, Y Yang, Z Zou - Cancer Immunology …, 2024 - Springer
As one of the scheduled immunization vaccines worldwide, virtually all individuals have
been vaccinated with BCG vaccine. In order to verify the hypothesis that delivering BCG high …

Adenovirus Vaccine Containing Truncated SARS-CoV-2 Spike Protein S1 Subunit Leads to a Specific Immune Response in Mice

K Chen, D Shi, C Li, Z Fang, Y Guo, W Jiang, J Li, H Li… - Vaccines, 2023 - mdpi.com
The development of an efficient and safe coronavirus disease 2019 (COVID-19) vaccine is a
crucial approach for managing the severe acute respiratory disease coronavirus 2 (SARS …