Neuronal cell death in the central nervous system has always been a challenging process to
decipher. In normal physiological conditions, neuronal cell death is restricted in the adult …

The lesions of Alzheimer disease include accumulation of proteins, losses of neurons and
synapses, and alterations related to reactive processes. Extracellular Aβ accumulation …

In the human brain and spinal cord, neurons degenerate after acute insults (eg, stroke,
cardiac arrest, trauma) and during progressive, adult-onset diseases [eg, amyotrophic lateral …

Mutations in the microtubule-associated protein tau gene have been linked to neurofibrillary
tangle (NFT) formation in several neurodegenerative diseases known as tauopathies; …

There are many lines of evidence showing that oxidative stress and aberrant mitogenic
changes have important roles in the pathogenesis of Alzheimer's disease (AD). However …

In situ end labeling combined with YOYO staining was used to mark apoptotic DNA
fragmentation and chromatin condensation respectively in human postmortem brain …

Neuronal loss is prominent in Alzheimer's disease (AD), and its mechanisms remain
unresolved. Apoptotic cell death has been implicated on the basis of studies demonstrating …

Acute stress suppresses new cell birth in the hippocampus in several species. Relatively
little is known, however, on how chronic stress affects the turnover, ie proliferation and …

Huntington's disease (HD) is a fatal inherited neurodegenerative disorder characterized by
personality changes, motor impairment, and subcortical dementia. HD is one of a number of …

Neuronal death is normal during nervous system development but is abnormal in brain and
spinal cord disease and injury. Apoptosis and necrosis are types of cell death. They are …