Chronic hepatitis C infection

HR Rosen - New England Journal of Medicine, 2011 - Mass Medical Soc
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Natural history of hepatitis C

S Lingala, MG Ghany - Gastroenterology Clinics, 2015 - gastro.theclinics.com
Hepatitis C virus (HCV) infection is an important cause of cirrhosis and hepatocellular
carcinoma (HCC) worldwide. 1 It is also a common cause of chronic liver disease in the …

Telaprevir for previously untreated chronic hepatitis C virus infection

IM Jacobson, JG McHutchison… - … England Journal of …, 2011 - Mass Medical Soc
Background In phase 2 trials, telaprevir, a hepatitis C virus (HCV) genotype 1 protease
inhibitor, in combination with peginterferon–ribavirin, as compared with peginterferon …

Origin, HDV genotype and persistent viremia determine outcome and treatment response in patients with chronic hepatitis delta

D Roulot, S Brichler, R Layese, Z BenAbdesselam… - Journal of …, 2020 - Elsevier
Background & Aims HDV infection causes severe chronic liver disease in individuals
infected with HBV. However, the factors associated with poor prognosis are largely …

[PDF][PDF] Diagnosis, management, and treatment of hepatitis C: an update

MG Ghany, DB Strader, DL Thomas, LB Seeff - Hepatology, 2009 - Wiley Online Library
Background The hepatitis C virus (HCV) is a major public health problem and a leading
cause of chronic liver disease. 5 An estimated 180 million people are infected worldwide. 6 …

A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus

L Prokunina-Olsson, B Muchmore, W Tang… - Nature …, 2013 - nature.com
Chronic infection with hepatitis C virus (HCV) is a common cause of liver cirrhosis and
cancer. We performed RNA sequencing in primary human hepatocytes activated with …

Response-guided telaprevir combination treatment for hepatitis C virus infection

KE Sherman, SL Flamm, NH Afdhal… - … England Journal of …, 2011 - Mass Medical Soc
Background Patients with chronic infection with hepatitis C virus (HCV) genotype 1 often
need 48 weeks of peginterferon–ribavirin treatment for a sustained virologic response. We …

Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus

AJ Thompson, AJ Muir, MS Sulkowski, D Ge, J Fellay… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: We recently identified a polymorphism upstream of interleukin (IL)-
28B to be associated with a 2-fold difference in sustained virologic response (SVR) rates to …

[HTML][HTML] Liver disease in women: the influence of gender on epidemiology, natural history, and patient outcomes

J Guy, MG Peters - Gastroenterology & hepatology, 2013 - ncbi.nlm.nih.gov
Women more commonly present with acute liver failure, autoimmune hepatitis, benign liver
lesions, primary biliary cirrhosis, and toxin-mediated hepatotoxicity. Women less commonly …

Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C …

PY Kwo, EJ Lawitz, J McCone, ER Schiff, JM Vierling… - The Lancet, 2010 - thelancet.com
Background Peginterferon plus ribavirin achieves sustained virological response (SVR) in
fewer than half of patients with genotype 1 chronic hepatitis C virus infection treated for 48 …