Ribosome biogenesis factors—from names to functions

K Dörner, C Ruggeri, I Zemp, U Kutay - The EMBO journal, 2023 - embopress.org
The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …

Ribosome assembly coming into focus

S Klinge, JL Woolford Jr - Nature reviews Molecular cell biology, 2019 - nature.com
In the past 25 years, genetic and biochemical analyses of ribosome assembly in yeast have
identified most of the factors that participate in this complex pathway and have generated …

Eukaryotic ribosome assembly

J Baßler, E Hurt - Annual review of biochemistry, 2019 - annualreviews.org
Ribosomes, which synthesize the proteins of a cell, comprise ribosomal RNA and ribosomal
proteins, which coassemble hierarchically during a process termed ribosome biogenesis …

An overview of pre‐ribosomal RNA processing in eukaryotes

AK Henras, C Plisson‐Chastang… - Wiley …, 2015 - Wiley Online Library
Ribosomal RNAs are the most abundant and universal noncoding RNAs in living organisms.
In eukaryotes, three of the four ribosomal RNAs forming the 40S and 60S subunits are borne …

Ribosome Biogenesis in the Yeast Saccharomyces cerevisiae

JL Woolford Jr, SJ Baserga - Genetics, 2013 - academic.oup.com
Ribosomes are highly conserved ribonucleoprotein nanomachines that translate information
in the genome to create the proteome in all cells. In yeast these complex particles contain …

Structures of the human and Drosophila 80S ribosome

AM Anger, JP Armache, O Berninghausen, M Habeck… - Nature, 2013 - nature.com
Protein synthesis in all cells is carried out by macromolecular machines called ribosomes.
Although the structures of prokaryotic, yeast and protist ribosomes have been determined …

Eukaryotic ribosome assembly, transport and quality control

C Peña, E Hurt, VG Panse - Nature structural & molecular biology, 2017 - nature.com
Eukaryotic ribosome synthesis is a complex, energy-consuming process that takes place
across the nucleolus, nucleoplasm and cytoplasm and requires more than 200 conserved …

Variant ribosomal RNA alleles are conserved and exhibit tissue-specific expression

MM Parks, CM Kurylo, RA Dass, L Bojmar, D Lyden… - Science …, 2018 - science.org
The ribosome, the integration point for protein synthesis in the cell, is conventionally
considered a homogeneous molecular assembly that only passively contributes to gene …

Functions of ribosomal proteins in assembly of eukaryotic ribosomes in vivo

J de la Cruz, K Karbstein… - Annual review of …, 2015 - annualreviews.org
The proteome of cells is synthesized by ribosomes, complex ribonucleoproteins that in
eukaryotes contain 79–80 proteins and four ribosomal RNAs (rRNAs) more than 5,400 …

In situ cryo-electron tomography reveals gradient organization of ribosome biogenesis in intact nucleoli

PS Erdmann, Z Hou, S Klumpe, S Khavnekar… - Nature …, 2021 - nature.com
Ribosomes comprise a large (LSU) and a small subunit (SSU) which are synthesized
independently in the nucleolus before being exported into the cytoplasm, where they …