The principles of ventilation and perfusion distribution in the lung form the foundation of
pulmonary physiology and remain cornerstones in caring for critically ill patients. Due to …

Acute respiratory distress syndrome is characterized by dyspnea at presentation, tachypnea
on physical examination, findings of bilateral infiltration in chest radiography, refractory …

The chicken major histocompatibility (B) complex (MHC) affects disease outcome
significantly. One of the best characterized systems of MHC control is the response to the …

The lungs of broilers are constantly challenged with lipopolysaccharide (LPS, endotoxin)
that can activate leukocytes and trigger thromboxane A 2 (TxA 2)-and serotonin (5HT) …

Bacterial endotoxins stimulate endothelin-mediated, thromboxane-dependent increases in
pulmonary vascular resistance in mammals, and thromboxane has been shown to cause an …

Hypoxic pulmonary vasoconstriction (HPV) is inhibited by inhaled nitric oxide (NO) in
healthy animals and is blunted in endotoxemia. We investigated whether the loss of HPV …

To elucidate the differential reactivity of pulmonary microvessels in the acini to hypoxia,
excessive CO2, and increased H+, we investigated changes in the diameter of precapillary …

Objectives: Acute lung injury and acute respiratory distress syndrome are characterized by
increased pulmonary artery pressure and ventilation-perfusion mismatch. We analyzed the …

Background Nonselective nitric oxide synthase (NOS) inhibition has detrimental effects in
sepsis because of inhibition of the physiologically important endothelial NOS (eNOS). The …

Pulmonary vasoconstriction in response to alveolar hypoxia (HPV) is frequently impaired in
patients with sepsis or acute respiratory distress syndrome or in animal models of …