Background In the 5 years that have passed since the publication of the 2018 International
Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR‐Allergic Rhinitis …

Histamine has an important role as a chemical messenger in physiologic responses,
neurotransmission, allergic inflammation, and immunomodulation by way of the H1-receptor …

The field of drug discovery has witnessed infinite development over the last decade with the
demand for discovery of novel efficient lead compounds. Although the development of novel …

Since the cloning of the histamine H3 receptor cDNA in 1999 by Lovenberg and co-workers,
this histamine receptor has gained the interest of many pharmaceutical companies as a …

Atopic diseases, such as asthma and allergic rhinitis, are common conditions that can
influence sleep and subsequent daytime functioning. Children and patients with allergic …

Abstract Study Objectives: To evaluate the efficacy and safety of doxepin 1, 3, and 6 mg in
insomnia patients. Design: Adults (18–64 y) with chronic primary insomnia (DSM-IV) were …

Nasal congestion, a common symptom related to allergic rhinitis (AR), often is associated
with poor sleep quality, leading to decreased learning ability, decreased productivity at work …

The subjective recording in diary cards of symptoms of itch, sneeze, nose running, and
blockage, with the use of a rating scale to indicate the level of severity, is usual for clinical …

Poor air quality has been shown to harm the health and development of children. Research
on these relationships has focused almost exclusively on the effects of human-made …

Antihistamines are useful medications for the treatment of a variety of allergic disorders.
Second-generation antihistamines avidly and selectively bind to peripheral histamine H 1 …