T cells of the γδ lineage are unconventional T cells with functions not restricted to MHC-
mediated antigen presentation. Because of their broad antigen specificity and NK-like …

Simple Summary Glioblastoma multiforme (GBM) is the most aggressive tumor type in the
central nervous system. Hypoxia, defined as a lack of sufficient oxygen in tissues, is the most …

The anatomic location and immunologic characteristics of brain tumors result in strong
lymphocyte suppression. Consequently, conventional immunotherapies targeting CD8 T …

Immunotherapy has limited efficacy against locally advanced pancreatic cancer (LAPC) due
to the presence of an immunosuppressive microenvironment (ISM). Irreversible …

Glioblastoma multiforme (GBM) is a brain tumor with a high mortality rate. Surgical resection
combined with radiotherapy and chemotherapy is the standard treatment for GBM patients …

Glioblastoma (GBM) represents the main form of brain tumors in adults, and one of the most
aggressive cancers overall. The treatment of GBM is a combination of surgery (when …

Adoptive cellular immunotherapy as a new paradigm to treat cancers is exemplified by the
FDA approval of six chimeric antigen receptor-T cell therapies targeting hematological …

Background Glioblastoma (GBM) is a highly aggressive primary brain tumor with a poor
prognosis. This study investigates the therapeutic potential of human Vγ9Vδ2 T cells in GBM …

Cancer treatment protocols depend on tumor type, localization, grade, and patient. Despite
aggressive treatments, median survival of patients with Glioblastoma (GBM), the most …

Primary CNS neoplasms are responsible for considerable mortality and morbidity, and many
therapies directed at primary brain tumors have proven unsuccessful despite their success …