Today HIV infection cannot be cured due to the presence of a reservoir of latently infected
cells inducing a viral rebound upon treatment interruption. Hence, the latent reservoir is …

Combinatory antiretroviral therapy (cART) reduces human immunodeficiency virus type 1
(HIV-1) replication but is not curative because cART interruption almost invariably leads to a …

Chromosomal integration of genome-intact HIV-1 sequences into the host genome creates a
reservoir of virally infected cells that persists throughout life, necessitating indefinite …

HIV-1 integration into the host genome favors actively transcribed genes. Prior work
indicated that the nuclear periphery provides the architectural basis for integration site …

One of the most explored therapeutic approaches aimed at eradicating HIV-1 reservoirs is
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells …

A hallmark of retroviral replication is establishment of the proviral state, wherein a DNA copy
of the viral RNA genome is stably incorporated into a host cell chromosome. Integrase is the …

Human immunodeficiency virus (HIV) infection is currently incurable, due to the persistence
of latently infected cells. The 'shock and kill'approach to a cure proposes to eliminate this …

Combinatory antiretroviral therapy (cART) increases the survival and quality of life of HIV-1-
infected patients. However, interruption of therapy almost invariably leads to the re …

Despite our ability to suppress HIV-1 replication indefinitely in people on optimal combined
antiretroviral therapy (cART), HIV-1 persists as a stably integrated and replication-competent …

HIV-1 recurrently targets active genes and integrates in the proximity of the nuclear pore
compartment in CD4+ T cells. However, the genomic features of these genes and the …