MAIT cell activation and dynamics associated with COVID-19 disease severity
T Parrot, JB Gorin, A Ponzetta, KT Maleki… - Science …, 2020 - science.org
Severe COVID-19 is characterized by excessive inflammation of the lower airways. The
balance of protective versus pathological immune responses in COVID-19 is incompletely …
balance of protective versus pathological immune responses in COVID-19 is incompletely …
Chemical modulators of mucosal associated invariant T cells
Conspectus Over the past decade, we have contributed to the chemistry of microbial natural
products and synthetic ligands, related to riboflavin and uracils, that modulate immune cells …
products and synthetic ligands, related to riboflavin and uracils, that modulate immune cells …
Emerging role for MAIT cells in control of antimicrobial resistance
Antimicrobial resistance is a serious threat to global public health as antibiotics are losing
effectiveness due to rapid development of resistance. The human immune system facilitates …
effectiveness due to rapid development of resistance. The human immune system facilitates …
MAIT and Vδ2 unconventional T cells are supported by a diverse intestinal microbiome and correlate with favorable patient outcome after allogeneic HCT
H Andrlová, O Miltiadous, AI Kousa, A Dai… - Science translational …, 2022 - science.org
Microbial diversity is associated with improved outcomes in recipients of allogeneic
hematopoietic cell transplantation (allo-HCT), but the mechanism underlying this …
hematopoietic cell transplantation (allo-HCT), but the mechanism underlying this …
[HTML][HTML] Single-cell transcriptional profiling reveals signatures of helper, effector, and regulatory MAIT cells during homeostasis and activation
Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that recognize
microbial vitamin B metabolites and have emerging roles in infectious disease …
microbial vitamin B metabolites and have emerging roles in infectious disease …
MAIT cell compartment characteristics are associated with the immune response magnitude to the BNT162b2 mRNA anti-SARS-CoV-2 vaccine
Mucosa-associated invariant T (MAIT) cells are unconventional T cells with innate-like
capacity to rapidly respond to microbial infection via MR1-restricted antigen recognition …
capacity to rapidly respond to microbial infection via MR1-restricted antigen recognition …
Type I interferons drive MAIT cell functions against bacterial pneumonia
JC López-Rodríguez, SJ Hancock, K Li… - Journal of Experimental …, 2023 - rupress.org
Mucosal-associated invariant T (MAIT) cells are abundant in the lung and contribute to host
defense against infections. During bacterial infections, MAIT cell activation has been …
defense against infections. During bacterial infections, MAIT cell activation has been …
[HTML][HTML] Expansion of donor-unrestricted MAIT cells with enhanced cytolytic function suitable for TCR redirection
T Parrot, K Healy, C Boulouis, MJ Sobkowiak… - JCI insight, 2021 - ncbi.nlm.nih.gov
Progress in our understanding of MR1-restricted mucosa-associated invariant T (MAIT) cells
has raised interest in harnessing these cells for immunotherapy. The innate-like response …
has raised interest in harnessing these cells for immunotherapy. The innate-like response …
Mucosal‐Associated invariant T cell dysregulation correlates with conjugated bilirubin level in chronic HBV infection
Y Liu, P Zhu, W Wang, X Tan, C Liu, Y Chen, R Pei… - …, 2021 - Wiley Online Library
Background and Aims Mucosal‐associated invariant T (MAIT) cells are nonconventional T
cells restricted to major histocompatibility complex class I–related protein 1 (MR1). They are …
cells restricted to major histocompatibility complex class I–related protein 1 (MR1). They are …
Hepatocellular carcinoma in acute hepatic porphyrias: results from the longitudinal study of the US Porphyrias Consortium
B Saberi, H Naik, JR Overbey, AL Erwin… - Hepatology, 2021 - journals.lww.com
Conclusion In this US study, 1.5% of patients with AHP had HCC. HCC in AHP occurred in
the absence of cirrhosis, which contrasts with other chronic liver diseases. Patients with …
the absence of cirrhosis, which contrasts with other chronic liver diseases. Patients with …