The endoplasmic reticulum (ER) represents the entry point into the secretory pathway where
nascent proteins encounter a specialized environment for their folding and maturation …

The eukaryotic heat shock response is an ancient and highly conserved transcriptional
program that results in the immediate synthesis of a battery of cytoprotective genes in the …

We have studied the effects of polysaccharide and protein crowding agents on the refolding
of oxidized and reduced hen lysozyme in order to test the prediction that association …

The mammalian protein disulphide-isomerase (PDI) family encompasses several highly
divergent proteins that are involved in the processing and maturation of secretory proteins in …

The molecular mechanism of action of macrophage migration inhibitory factor (MIF), a
cytokine with a critical role in the immune and inflammatory response, has not yet been …

Whereas newly synthesized proteins that have aquired a properly folded and assembled
structure are transported from the endoplasmic reticulum to their final destinations …

Macrophage migration inhibitory factor (MIF) has been proposed to be the physiologic
counter-regulator of glucocorticoid action within the immune system. In this role, MIF's …

Prolyl 4-hydroxylases catalyze the formation of 4-hydroxyproline in collagens and other
proteins with an appropriate collagen-like stretch of amino acid residues. The enzyme …

Protein disulfide isomerase (PDI) is a protein-thiol oxidoreductase that catalyzes the
oxidation, reduction and isomerization of protein disulfides. In the endoplasmic reticulum …

Prolyl 4-hydroxylases (EC 1.14. 11.2) catalyze the formation of 4-hydroxyproline in
collagens and other proteins with collagen-like sequences. The vertebrate type I and type II …