This review is an attempt to retrace the chronicle that starts from the discovery of the role of
nickel as the essential metal ion in urease for the enzymatic catalysis of urea, a key step in …

Ureases (urea amidohydrolases, EC 3.5. 1.5) are a group of highly proficient enzymes,
widely distributed in nature, whose catalytic function is to catalyze the hydrolysis of urea, its …

This review describes the functions, structures, and mechanisms of nine nickel-containing
enzymes: glyoxalase I, acireductone dioxygenase, urease, superoxide dismutase,[NiFe] …

The importance of nickel enzymes, where nickel serves as an essential cofactor, in Archaea,
bacteria, plants, and primitive eukaryotes, is well documented. 1 Despite the fact that no …

Helicobacter pylori, an etiologic agent in a variety of gastroduodenal diseases, produces a
large amount of urease, which is believed to neutralize gastric acid by producing ammonia …

The amidohydrolase superfamily comprises a remarkable set of enzymes that catalyze the
hydrolysis of a wide range of substrates bearing amide or ester functional groups at carbon …

Revised and updated, Chemical Reagents for Protein Modification, Third Edition is an
encyclopedic work describing the many approaches to the site-specific modification of …

Urease, the first enzyme to be crystallized, contains a dinuclear nickel metallocenter that
catalyzes the decomposition of urea to produce ammonia, a reaction of great agricultural …

Infection of the human stomach by Helicobacter pylori remains a worldwide problem and
greatly contributes to peptic ulcer disease and gastric cancer. Without active intervention …

The broad distribution of ureases in leguminous seeds, as well as the accumulation pattern
of the protein during seed maturation, are suggestive of an important physiological role for …