Gap junctions are essential to the function of multicellular animals, which require a high
degree of coordination between cells. In vertebrates, gap junctions comprise connexins and …

Connexins are a family of transmembrane proteins that play a key role in cardiac physiology.
Gap junctional channels put into contact the cytoplasms of connected cardiomyocytes …

Inherited or acquired alterations in the structure and function of connexin proteins have long
been associated with disease. In the present work, we review current knowledge on the role …

Abstract FAT atypical cadherin 1 (FAT1), which encodes a protocadherin, is one of the most
frequently mutated genes in human cancer. Over the past 20 years, the role of FAT1 in tissue …

About a decade ago, the molecular determinants controlling the opening and closing of
Cx43 gap junction channels have been identified. Advanced biophysical approaches …

Coordinated electrical activity in the heart is supported by gap junction channels located at
the intercalated discs of cardiomyocytes. Impaired gap junctional communication between …

Coordinated electrical activation of the heart is essential for the maintenance of a regular
cardiac rhythm and effective contractions. Action potentials spread from one cell to the next …

Co-ordinated electrical activation of the heart is maintained by intercellular coupling of
cardiomyocytes via gap junctional channels located in the intercalated disks. These …

In the normal liver, cells interact closely through gap junctions. By providing a pathway for
the trafficking of low molecular mass molecules, these channels contribute to tissue …

Osteoblasts, osteocytes, and osteoprogenitor cells are interconnected into a functional
network by gap junctions formed primarily by connexin43 (Cx43). Over the past two …