Heme (protoheme IX) is an essential cofactor for a large variety of proteins whose functions
vary from one electron reactions to binding gases. While not ubiquitous, heme is found in the …

Tetrapyrroles represent a unique class of natural products that possess diverse chemical
architectures and exhibit a broad range of biological functions. Accordingly, they attract keen …

Monoderm bacteria accumulate heme b via the coproporphyrin-dependent biosynthesis
pathway. In the final step, in the presence of two molecules of H2O2, the propionate groups …

The final three steps of heme biogenesis exhibit notable differences between di-and mono-
derm bacteria. The former employs the protoporphyrin-dependent (PPD) pathway, while the …

The identification of the coproporphyrin‐dependent heme biosynthetic pathway, which is
used almost exclusively by monoderm bacteria in 2015 by Dailey et al. triggered studies …

Coproheme decarboxylases (ChdCs) are utilized by monoderm bacteria to produce heme b
by a stepwise oxidative decarboxylation of the 2-and 4-propionate groups of iron …

Coproheme decarboxylase (ChdC) is an important enzyme in the coproporphyrin-
dependent pathway (CPD) of Gram-positive bacteria that decarboxylates coproheme on two …

Prokaryotic heme biosynthesis in Gram‐positive bacteria follows the coproporphyrin‐
dependent heme biosynthesis pathway. The last step in this pathway is catalyzed by the …

This work focuses on the carbon monoxide adducts of the wild-type and selected variants of
the coproheme decarboxylase from actinobacterial Corynebacterium diphtheriae complexed …

Iron insertion into porphyrins is an essential step in heme biosynthesis. In the
coproporphyrin-dependent pathway, specific to monoderm bacteria, this reaction is …