Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …

Tissue microcirculation is essential for the maintenance of organ homeostasis. Following
acute infections, activation of coagulation and inflammation, which are critical …

Trauma is a leading cause of death and morbidity worldwide. Here, we present the analysis
of a longitudinal multi-omic dataset comprising clinical, cytokine, endotheliopathy biomarker …

Vascular endothelial injury is a hallmark of acute infection at both the microvascular and
macrovascular levels. The hallmark of SARS‐CoV‐2 infection is the current COVID‐19 …

Infection by SARS-CoV-2 is associated with a high risk of thrombosis. The laboratory
documentation of hypercoagulability and impaired fibrinolysis remains a challenge. Our aim …

Background Postpartum hemorrhage (PPH) may be exacerbated by hemostatic impairment.
Information about PPH-associated coagulopathy is limited, often resulting in treatment …

The COVID-19 pandemic has introduced a global public health threat unparalleled in our
history. The most severe cases are marked by ARDS attributed to microvascular thrombosis …

This clinical review explored coagulopathy in severely bleeding patients after major surgery
(eg, cardiac surgery with cardiopulmonary bypass or CPB), serious trauma, and postpartum …

Disseminated intravascular coagulation (DIC) has been understood as a consumptive
coagulopathy. However, impaired hemostasis is a component of DIC that occurs in a …

Irrespective of the reason for hypoperfusion, hypocoagulable and/or hyperfibrinolytic
hemostatic aberrancies afflict up to one-quarter of critically ill patients in shock. Intensivists …