Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

Magnesium, the second most abundant cellular cation after potassium, is essential to
regulate numerous cellular functions and enzymes, including ion channels, metabolic …

▪ Abstract The aim of this review is to provide a basic framework for understanding the
function of mammalian transient receptor potential (TRP) channels, particularly as they have …

NITRIC oxide is the major endothelium-derived relaxing factor (EDRF) 1–3, and it is thought
to relax smooth muscle cells by stimulation of guanylate cyclase, accumulation of its product …

The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously
expressed chanzyme that possesses an ion channel permeable to the divalent cations …

Eight members of the TRP-melastatin (TRPM) subfamily have been identified, whose
physiological functions and distribution are poorly characterized. Although tissue expression …

Sustained elevation in the intracellular Ca2+ concentration via Ca2+ influx, which is
activated by a variety of mechanisms, plays a central regulatory role for cardiovascular …

Triggered activity in cardiac muscle and intracellular Ca2+ have been linked in the past.
However, today not only are there a number of cellular proteins that show clear Ca2+ …

Significant progress in the molecular and functional characterization of a subfamily of genes
that encode melastatin-related transient receptor potential (TRPM) cation channels has …

A large number of mammalian Mg2+ transporters have been hypothesized on the basis of
physiological data, but few have been investigated at the molecular level. The recent …