Transmembrane ATPases are membrane-bound enzyme complexes and ion transporters
that can be divided into F-, V-, and A-ATPases according to their structure. The V-ATPases …

Abstract The vacuolar H+-ATPases (V-ATPases) are essential, ATP-dependent proton
pumps present in a variety of eukaryotic cellular membranes. Intracellularly, V-ATPase …

Despite the challenges posed by drug resistance and side effects, chemotherapy remains a
pivotal strategy in cancer treatment. A key issue in this context is macroautophagy …

With the advent of nanotechnology, various modes of traditional treatment strategies have
been transformed extensively owing to the advantageous morphological, physiochemical …

Ovarian cancer has the highest mortality rate among all gynecologic cancers, with most
patients presenting with advanced stage tumors. About a third of patients do not respond to …

Resistance to chemotherapeutics and targeted drugs is one of the main problems in
successful cancer therapy. Various mechanisms have been identified to contribute to drug …

The tumor microenvironment (TME) components play a crucial role in cancer cells'
resistance to chemotherapeutic agents. This phenomenon is exceptionally fundamental in …

PHY34 is a synthetic small molecule, inspired by a compound naturally occurring in tropical
plants of the Phyllanthus genus. PHY34 was developed to have potent in vitro and in vivo …

Background and Aims How Wnt signaling is orchestrated in liver regeneration and
tumorigenesis remains elusive. Recently, we identified transmembrane protein 9 (TMEM9) …

The control of the intracellular pH is vital for the survival of all organisms. Membrane
transporters, both at the plasma and intracellular membranes, are key players in maintaining …