Investigations on the interface of nucleic acid aptamers and binding targets

S Cai, J Yan, H Xiong, Y Liu, D Peng, Z Liu - Analyst, 2018 - pubs.rsc.org
Nucleic acid aptamers are single-stranded DNA or RNA of 20–100 nucleotides in length that
have attracted substantial scientific interest due to their ability to specifically bind to target …

Aptamers targeting SARS-COV-2: a promising tool to fight against COVID-19

Y Zhang, M Juhas, CK Kwok - Trends in Biotechnology, 2023 - cell.com
SARS-CoV-2, the causative agent of COVID-19, remains among the main causes of global
mortality. Although antigen/antibody-based immunoassays and neutralizing antibodies …

[HTML][HTML] Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters

S Yuan, R Wang, JFW Chan, AJ Zhang, T Cheng… - Nature …, 2020 - nature.com
SARS-CoV-2 is causing a pandemic of COVID-19, with high infectivity and significant
mortality. Currently, therapeutic options for COVID-19 are limited. Historically, metal …

[HTML][HTML] Application of aptamers in virus detection and antiviral therapy

X Zou, J Wu, J Gu, L Shen, L Mao - Frontiers in microbiology, 2019 - frontiersin.org
Viral infections can cause serious diseases for humans and animals. Accurate and early
detection of viruses is often crucial for clinical diagnosis and therapy. Aptamers are mostly …

Nucleic acid aptamer-based methods for diagnosis of infections

KS Park - Biosensors and Bioelectronics, 2018 - Elsevier
Infectious diseases are a serious global problem, which not only take an enormous human
toll but also incur tremendous economic losses. In combating infectious diseases, rapid and …

Assays to estimate the binding affinity of aptamers

R Thevendran, M Citartan - Talanta, 2022 - Elsevier
Aptamers have become coming-of-age molecular recognition elements in both diagnostic
and therapeutic applications. Generated by SELEX, the 'quality control'of aptamers, which …

The influenza virus polymerase complex: an update on its structure, functions, and significance for antiviral drug design

A Stevaert, L Naesens - Medicinal research reviews, 2016 - Wiley Online Library
Influenza viruses cause seasonal epidemics and pandemic outbreaks associated with
significant morbidity and mortality, and a huge cost. Since resistance to the existing anti …

Aptamers for viral detection and inhibition

B Chakraborty, S Das, A Gupta, Y Xiong… - ACS infectious …, 2022 - ACS Publications
Recent times have experienced more than ever the impact of viral infections in humans.
Viral infections are known to cause diseases not only in humans but also in plants and …

[HTML][HTML] Aptamers against viruses: Selection strategies and bioanalytical applications

E Sánchez-Báscones, F Parra… - TrAC Trends in Analytical …, 2021 - Elsevier
Viruses are infectious agents that can only replicate inside cells. Tests available to make an
early and effective diagnosis of viral diseases are mainly based on PCR, the gold-standard …

[HTML][HTML] Use of aptamers as diagnostics tools and antiviral agents for human viruses

VM González, ME Martín, G Fernández… - Pharmaceuticals, 2016 - mdpi.com
Appropriate diagnosis is the key factor for treatment of viral diseases. Time is the most
important factor in rapidly developing and epidemiologically dangerous diseases, such as …