Bacteria in the genus Brucella are important human and veterinary pathogens. The abortion
and infertility they cause in food animals produce economic hardships in areas where the …

Immunotherapy has been emerging as a powerful strategy for cancer management.
Recently, accumulating evidence has demonstrated that bacteria-based immunotherapy …

Spleen tyrosine kinase (SYK) is a critical immune signaling molecule and therapeutic target.
We identified damaging monoallelic SYK variants in six patients with immune deficiency …

Macrophages are the first encounters of invading bacteria and are responsible for engulfing
and digesting pathogens through phagocytosis leading to initiation of the innate …

Brucellosis is a zoonotic infectious disease caused by bacteria of the genus Brucella.
Brucella melitensis, Brucella abortus, and Brucella suis are the most pathogenic species of …

Brucellosis is considered one of the major zoonoses worldwide, constituting a critical
livestock and human health concern with a huge socio-economic burden. Brucella genus, its …

Immunological interdependence between the two eyes has been reported for the cornea
and the retina but not for the ocular mucosal surface. Intriguingly, patients frequently report …

Brucella abortus, the causative agent of brucellosis, displays many resources to evade T cell
responses conducive to persist inside the host. Our laboratory has previously showed that …

Pathogenic microorganisms confront several proteolytic events in the molecular interplay
with their host, highlighting that proteolysis and its regulation play an important role during …

In this work, we evaluated recombinant receptor binding domain (RBD)-based vaccine
formulation prototypes with potential for further clinical development. We assessed different …