Abstract Mitochondria contain about 1,000–1,500 proteins that fulfil multiple functions.
Mitochondrial proteins originate from two genomes: mitochondrial and nuclear. Hence …

Mitochondria are cellular organelles responsible for generation of chemical energy in the
process called oxidative phosphorylation. They originate from a bacterial ancestor and …

Aggressive and metastatic cancers show enhanced metabolic plasticity, but the precise
underlying mechanisms of this remain unclear. Here we show how two NOP2/Sun RNA …

Aging is typified by a progressive decline in mitochondrial activity and stress resilience.
Here, we review how mitochondrial stress pathways have pleiotropic effects on cellular and …

Loss of proteostasis is a fundamental process driving aging. Proteostasis is affected by the
accuracy of translation, yet the physiological consequence of having fewer protein synthesis …

Redox biology is at the core of life sciences, accompanied by the close correlation of redox
processes with biological activities. Redox homeostasis is a prerequisite for human health …

Respiratory chains are crucial for cellular energy conversion and consist of multi‐subunit
complexes that can assemble into supercomplexes. These structures have been intensively …

Expansion of antigen-experienced CD8+ T cells is critical for the success of tumour-
infiltrating lymphocyte (TIL)-adoptive cell therapy (ACT) in patients with cancer. Interleukin-2 …

Ageing is a complex trait controlled by genes and the environment. The highly conserved
mechanistic target of rapamycin signalling pathway (mTOR) is a major regulator of lifespan …

Since the identification and definition of the hallmarks of aging, these aspects of molecular
and cellular decline have been most often described as isolated or distinct mechanisms …