Marine pharmacology in 2018: Marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis and antiviral activities; …
AMS Mayer, ML Pierce, K Howe, AD Rodríguez… - Pharmacological …, 2022 - Elsevier
The 2018 marine pharmacology literature review represents a continuation of the previous
11 reviews of a series initiated in 1998. Preclinical marine pharmacology research during …
11 reviews of a series initiated in 1998. Preclinical marine pharmacology research during …
Mapping of mTOR drug targets: Featured platforms for anti-cancer drug discovery
The mammalian/mechanistic target of rapamycin (mTOR) is a regulatory protein kinase
involved in cell growth and proliferation. mTOR is usually assembled in two different …
involved in cell growth and proliferation. mTOR is usually assembled in two different …
Potential Drugs Targeting Early Innate Immune Evasion of SARS-Coronavirus 2 via 2'-O-Methylation of Viral RNA
JA Encinar, JA Menendez - Viruses, 2020 - mdpi.com
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causing the COVID-19
respiratory disease pandemic utilizes unique 2′-o-methyltransferase (2′-O-MTase) …
respiratory disease pandemic utilizes unique 2′-o-methyltransferase (2′-O-MTase) …
Bisphenol-S and Bisphenol-F alter mouse pancreatic β-cell ion channel expression and activity and insulin release through an estrogen receptor ERβ mediated …
Abstract Bisphenol-S (BPS) and Bisphenol-F (BPF) are current Bisphenol-A (BPA)
substitutes. Here we used pancreatic β-cells from wild type (WT) and estrogen receptor β …
substitutes. Here we used pancreatic β-cells from wild type (WT) and estrogen receptor β …
[HTML][HTML] An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter β-TrCP delivers anti-inflammatory responses in mouse …
It is widely accepted that activating the transcription factor NRF2 will blast the physiological
anti-inflammatory mechanisms, which will help combat pathologic inflammation. Much effort …
anti-inflammatory mechanisms, which will help combat pathologic inflammation. Much effort …
Marine-derived natural products as ATP-competitive mTOR kinase inhibitors for cancer therapeutics
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase portraying a
quintessential role in cellular proliferation and survival. Aberrations in the mTOR signaling …
quintessential role in cellular proliferation and survival. Aberrations in the mTOR signaling …
The multitarget activity of natural extracts on cancer: Synergy and xenohormesis
M Herranz-López, M Losada-Echeberría… - Medicines, 2018 - mdpi.com
It is estimated that over 60% of the approved drugs and new drug developments for cancer
and infectious diseases are from natural origin. The use of natural compounds as a potential …
and infectious diseases are from natural origin. The use of natural compounds as a potential …
Differential effects of IGF-1R small molecule tyrosine kinase inhibitors BMS-754807 and OSI-906 on human cancer cell lines
M Fuentes-Baile, MP Ventero, JA Encinar… - Cancers, 2020 - mdpi.com
Simple Summary We have tested the effects of IGF-1R tyrosine kinase inhibitors BMS-
754807 (BMS) and OSI-906 (OSI) on human colon, pancreatic carcinoma cell, and …
754807 (BMS) and OSI-906 (OSI) on human colon, pancreatic carcinoma cell, and …
Epicatechin and β-Glucan from Whole Highland Barley Grain Synergistic Benefit on Attenuating Hyperglycemia via Improving Hepatic Glucose Metabolism in Diabetic …
Z Liu, Z Zhang, R Tang, J Liu… - Journal of Agricultural and …, 2024 - ACS Publications
Our previous study proved that epicatechin (EC) and β-glucan (BG) from whole-grain
highland barley synergistically modulate glucose metabolism in insulin-resistant HepG2 …
highland barley synergistically modulate glucose metabolism in insulin-resistant HepG2 …
The extra virgin olive oil phenolic oleacein is a dual substrate-inhibitor of catechol-O-methyltransferase
E Cuyàs, S Verdura, J Lozano-Sánchez… - Food and Chemical …, 2019 - Elsevier
Catechol-containing polyphenols present in coffee and tea, while serving as excellent
substrates for catechol-O-methyltransferase (COMT)-catalyzed O-methylation, can also …
substrates for catechol-O-methyltransferase (COMT)-catalyzed O-methylation, can also …