Epithelial cells display dynamic behaviours, such as rearrangement, movement and shape
changes, particularly during embryonic development and in equivalent processes in adults …

Successful implantation is the result of reciprocal interactions between the implantation-
competent blastocyst and receptive uterus. Although various cellular aspects and molecular …

Adherens junctions (AJs), which are organized by adhesion proteins and the underlying
actin cytoskeleton, probably sense pulling forces from adjacent cells and modulate opposing …

Cell shape changes underlie a large set of biological processes ranging from cell division to
cell motility. Stereotyped patterns of cell shape changes also determine tissue remodeling …

Understanding preimplantation development is important both for basic reproductive biology
and for practical applications including regenerative medicine and livestock breeding …

The anterior-posterior axis of the mouse embryo is defined before formation of the primitive
streak, and axis specification and subsequent anterior development involves signaling from …

Gene knockout technology has provided a powerful tool for functional analyses of genes
expressed preferentially in a particular tissue. Given marked similarities between human …

The Hippo pathway regulates contact inhibition of cell proliferation and, ultimately, organ
size in diverse multicellular organisms. Inactivation of the Hippo pathway promotes nuclear …

Connections between the cytoskeleton and intercellular junctions profoundly influence cell
shape and motility. It is becoming increasingly clear that in addition to structural functions …

We disrupted the Mcl-1 locus in murine ES cells to determine the developmental roles of this
Bcl-2 family member. Deletion of Mcl-1 resulted in peri-implantation embryonic lethality. Mcl …