Severe hemolysis or myolysis occurring during pathological states, such as sickle cell
disease, ischemia reperfusion, and malaria results in high levels of free heme, causing …

There is a great deal of evidence to support a pathogenic role of oxidative stress in
Alzheimer's disease (AD), but the sources of reactive oxygen species have not been directly …

Heme and iron metabolism are of considerable interest and importance in normal brain
function as well as in neurodegeneration and neuropathologically following traumatic injury …

Alzheimer's disease (AD) is characterized by the presence of neurofibrillary tangles, senile
plaques and loss of synapses. There is accumulating evidence that oxidative stress plays an …

Heme, a major functional form of iron in the cell, is synthesized in the mitochondria by
ferrochelatase inserting ferrous iron into protoporphyrin IX. Heme deficiency was induced …

Heme, the major functional form of iron, is synthesized in the mitochondria. Although
disturbed heme metabolism causes mitochondrial decay, oxidative stress, and iron …

Proteolytic processing and phosphorylation of amyloid precursor protein (APP), and
hyperphosphorylation of tau protein, have been shown to be increased in Alzheimer's …

Heme is present in all cells, acting as a cofactor in essential metabolic pathways such as
respiration and photosynthesis. Moreover, both heme and its degradation products, CO, iron …

Oxidative damage of biological macromolecules is a hallmark of most neurodegenerative
disorders such as Alzheimer, Parkinson and diffuse Lewy body diseases. Another important …

Abnormalities in the metabolism of the transition metals iron and copper have been
demonstrated to play a crucial role in the pathogenesis of various neurodegenerative …