Introduction Monogenic diabetes, a form of diabetes mellitus, is caused by a mutation in a
single gene and may account for 1–2% of all clinical forms of diabetes. To date, more than …

Vertebrate pancreas organogenesis is a stepwise process regulated by a complex network
of signaling and transcriptional events, progressively steering the early endoderm toward …

Sequence variants in cis-acting enhancers are important for polygenic disease, but their role
in Mendelian disease is poorly understood. Redundancy between enhancers that regulate …

The pancreas is a central organ for human diseases. Most alleles uncovered by genome-
wide association studies of pancreatic dysfunction traits overlap with non-coding sequences …

Monogenetic forms of diabetes represent 1%–5% of all diabetes cases and are caused by
mutations in a single gene. These mutations, that affect genes involved in pancreatic β-cell …

Neonatal diabetes is diagnosed before the age of 6 months and is usually caused by single‐
gene mutations. More than 30 genetic causes of neonatal diabetes have been described to …

Neonatal diabetes mellitus (NDM), defined as diabetes with an onset during the first 6
months of life, is a rare form of monogenic diabetes. The initial publications on this condition …

Abstract Neonatal Diabetes Mellitus (NDM) is diagnosed in the first 6 months of life and is
most likely to have a monogenic cause rather than being polygenic type 1 diabetes. Before …

Monogenic causes of neonatal diabetes are characterized by variable degree of restriction
of growth in utero because of deficiency of insulin that depends on the specific gene cause …

Neonatal diabetes mellitus (NDM) is a rare form of diabetes with onset in the first 6 months of
life. NDM is genetically heterogeneous, involving more than 40 loci most of which cause non …