The advent of functional genomics has enabled the molecular biosciences to come a long
way towards characterizing the molecular constituents of life. Yet, the challenge for biology …

Unicellular flagellates of the family Trypanosomatidae are obligatory parasites of
invertebrates, vertebrates and plants. Dixenous species are aetiological agents of a number …

A set of linear pathways often does not capture the full range of behaviors of a metabolic
network. The concept of 'elementary flux modes' provides a mathematical tool to define and …

This paper examines whether the in vivo behavior of yeast glycolysis can be understood in
terms of the in vitro kinetic properties of the constituent enzymes. In nongrowing, anaerobic …

Application of metabolic engineering principles to the rational design of microbial production
processes crucially depends on the ability to describe quantitatively the systemic behavior of …

Protozoan Kinetoplastida, including the pathogenic trypanosomatids of the genera
Trypanosoma and Leishmania, compartmentalize several important metabolic systems in …

Glycolysis is perceived as a promising target for new drugs against parasitic trypanosomatid
protozoa because this pathway plays an essential role in their ATP supply. Trypanosomatid …

Metabolic control analysis (MCA) provides a quantitative description of substrate flux in
response to changes in system parameters of complex enzyme systems. Medical …

While gene expression is a fundamental and tightly controlled cellular process that is
regulated at multiple steps, the exact contribution of each step remains unknown in any …

Lysine lactylation has been recognized as a novel post-translational modification occurring
on histones. However, lactylation in non-histone proteins, especially in proteins of early …