[HTML][HTML] Cardiovascular Manifestations and Management in Autosomal Dominant Polycystic Kidney Disease

PS Sagar, GK Rangan - Kidney International Reports, 2023 - Elsevier
Cardiovascular disease is the major cause of mortality in autosomal dominant polycystic
kidney disease and contributes to significant burden of disease. The manifestations are …

Culture of Three-Dimensional Madin–Darby Canine Kidney (MDCK) Cysts for In Vitro Drug Testing in Polycystic Kidney Disease

S Saravanabavan, GK Rangan - Kidney Research: Experimental …, 2023 - Springer
The formation and growth of kidney cysts (fluid-filled structures lined by epithelial cells) is the
primary pathological abnormality in polycystic kidney disease (PKD). Multiple molecular …

[HTML][HTML] Randomized Trial of Nitrate-Replete Beetroot Juice on Blood Pressure in Hypertensive Adults with ADPKD

PS Sagar, J Elhindi, K Chau, DC Harris, V Lee… - Kidney International …, 2024 - Elsevier
Reduced circulating levels of nitric oxide metabolites are hypothesized, in part, to drive
hypertension in autosomal dominant polycystic kidney disease (ADPKD). 1 Beetroot juice …

Potential Therapeutic Interventions for Cardiovascular Disease in Autosomal Dominant Polycystic Kidney Disease

P Sagar - 2024 - ses.library.usyd.edu.au
Cardiovascular disease (CVD) is a major cause of morbidity and mortality in autosomal
dominant polycystic kidney disease (ADPKD). While the current interventions are …

Efficacy of beetroot juice on reducing blood pressure in hypertensive adults with autosomal dominant polycystic kidney disease (BEET-PKD): study protocol for a …

PS Sagar, A Munt, S Saravanabavan, FA Vahedi… - Trials, 2023 - Springer
Background In autosomal dominant polycystic kidney disease (ADPKD) impaired nitric oxide
(NO) synthesis, in part, contributes to early-onset hypertension. Beetroot juice (BRJ) reduces …

cGMP imaging uncovers new roles and therapeutic implications of NO/cGMP signaling in the kidney and in melanoma

D Stehle - 2024 - tobias-lib.ub.uni-tuebingen.de
Generation of cyclic guanosine monophosphate (cGMP) via nitric oxide (NO)-sensitive
guanylyl cyclase (NO GC) has been implicated in the regulation of many physiological …

Effects of chronic administration of different doses of nitrate on renal function in female rats.

M Shokri, A Ghasemi - 2021 - cabidigitallibrary.org
Introduction: As a nitric oxide (NO) donor, nitrate administration improves renal function in
male animals. This study aims to determine the effects of chronic administration of different …