Bacterial NLR-related proteins protect against phage

EM Kibby, AN Conte, AM Burroughs, TA Nagy… - Cell, 2023 - cell.com
Bacteria use a wide range of immune pathways to counter phage infection. A subset of these
genes shares homology with components of eukaryotic immune systems, suggesting that …

Actinomycetes biosynthetic potential: how to bridge in silico and in vivo?

Y Rebets, E Brötz, B Tokovenko… - Journal of Industrial …, 2014 - academic.oup.com
Actinomycetes genome sequencing and bioinformatic analyses revealed a large number of
“cryptic” gene clusters coding for secondary metabolism. These gene clusters have the …

Synergistic action of phage and antibiotics: parameters to enhance the killing efficacy against mono and dual-species biofilms

E Akturk, H Oliveira, SB Santos, S Costa, S Kuyumcu… - Antibiotics, 2019 - mdpi.com
Pseudomonas aeruginosa and Staphylococcus aureus are opportunistic pathogens and are
commonly found in polymicrobial biofilm-associated diseases, namely chronic wounds …

Two phages, phiIPLA-RODI and phiIPLA-C1C, lyse mono-and dual-species staphylococcal biofilms

D Gutiérrez, D Vandenheuvel, B Martínez… - Applied and …, 2015 - Am Soc Microbiol
Phage therapy is a promising option for fighting against staphylococcal infections. Two lytic
phages, vB_SauM_phiIPLA-RODI (phiIPLA-RODI) and vB_SepM_phiIPLA-C1C (phiIPLA …

[HTML][HTML] Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors

X Xiong, S Tian, P Yang, F Lebreton, H Bao, K Sheng… - Cell, 2022 - cell.com
Enterococci are a part of human microbiota and a leading cause of multidrug resistant
infections. Here, we identify a family of Enterococcus pore-forming toxins (Epxs) in E …

Isolation and characterization of a lytic bacteriophage against Pseudomonas aeruginosa

S Sharma, S Datta, S Chatterjee, M Dutta, J Samanta… - Scientific Reports, 2021 - nature.com
In recent years, the use of bacteriophages (or'phages') against multidrug-resistant (MDR)
bacteria including Pseudomonas aeruginosa has drawn considerable attention, globally. In …

Development of a Phage Cocktail to Control Proteus mirabilis Catheter-associated Urinary Tract Infections

LDR Melo, P Veiga, N Cerca, AM Kropinski… - Frontiers in …, 2016 - frontiersin.org
Proteus mirabilis is an enterobacterium that causes catheter-associated urinary tract
infections (CAUTIs) due to its ability to colonize and form crystalline biofilms on the catheters …

Phage annotation guide: guidelines for assembly and high-quality annotation

D Turner, EM Adriaenssens, I Tolstoy, AM Kropinski - Phage, 2021 - liebertpub.com
All sequencing projects of bacteriophages (phages) should seek to report an accurate and
comprehensive annotation of their genomes. This article defines 14 questions for those new …

Designing P. aeruginosa synthetic phages with reduced genomes

DP Pires, R Monteiro, D Mil-Homens, A Fialho, TK Lu… - Scientific reports, 2021 - nature.com
In the era where antibiotic resistance is considered one of the major worldwide concerns,
bacteriophages have emerged as a promising therapeutic approach to deal with this …

Bacteriophage cocktail significantly reduces Escherichia coli O157: H7 contamination of lettuce and beef, but does not protect against recontamination

CD Carter, A Parks, T Abuladze, M Li, J Woolston… - …, 2012 - Taylor & Francis
Foods contaminated with Escherichia coli O157: H7 cause more than 63,000 foodborne
illnesses in the United States every year, resulting in a significant economic impact on …