Regulation of EMT in colorectal cancer: a culprit in metastasis

T Vu, PK Datta - Cancers, 2017 - mdpi.com
Epithelial to mesenchymal transition (EMT) is a process during which cells lose their
epithelial characteristics, for instance cell polarity and cell–cell contact, and gain …

The roles of integrin αvβ6 in cancer

J Niu, Z Li - Cancer letters, 2017 - Elsevier
Integrins are a family of heterodimeric cell surface receptors that are expressed in most cells,
where they mediate cell-cell and cell-extracellular matrix (ECM) interactions. Integrin αvβ6 is …

[HTML][HTML] Systematic review of the old and new concepts in the epithelial-mesenchymal transition of colorectal cancer

S Gurzu, C Silveanu, A Fetyko, V Butiurca… - World journal of …, 2016 - ncbi.nlm.nih.gov
Epithelial-to-mesenchymal transition (EMT) is defined as the transformation of an epithelial
cell into a spindle cell with the loss of membrane E-cadherin expression and the gain of …

[HTML][HTML] Modulation of intestinal barrier function by glucocorticoids: Lessons from preclinical models

M Tena-Garitaonaindia, M Arredondo-Amador… - Pharmacological …, 2022 - Elsevier
Glucocorticoids (GCs) are widely used drugs for their anti-inflammatory and
immunosuppressant effects, but they are associated with multiple adverse effects. Despite …

Histone deacetylase 3 promotes alveolar epithelial–mesenchymal transition and fibroblast migration under hypoxic conditions

SH Jeong, ES Son, YE Lee, SY Kyung… - … & Molecular Medicine, 2022 - nature.com
Abstract Epithelial–mesenchymal transition (EMT), a process by which epithelial cells
undergo a phenotypic conversion that leads to myofibroblast formation, plays a crucial role …

[HTML][HTML] Emodin inhibits colon cancer cell invasion and migration by suppressing epithelial–mesenchymal transition via the Wnt/β-Catenin pathway

J Gu, C Cui, L Yang, L Wang, X Jiang - Oncology research, 2019 - ncbi.nlm.nih.gov
Colon cancer (CC) is the third most common cancer worldwide. Emodin is an anthraquinone-
active substance that has the ability to affect tumor progression. Our study aims to explore …

DeepDRA: Drug repurposing using multi-omics data integration with autoencoders

T Mohammadzadeh-Vardin, A Ghareyazi… - Plos one, 2024 - journals.plos.org
Cancer treatment has become one of the biggest challenges in the world today. Different
treatments are used against cancer; drug-based treatments have shown better results. On …

Intraoperative dexamethasone decreases infectious complications after pancreaticoduodenectomy and is associated with long-term survival in pancreatic cancer

M Sandini, KJ Ruscic, CR Ferrone, AL Warshaw… - Annals of Surgical …, 2018 - Springer
Background Dexamethasone is administered intraoperatively to prevent anesthesia-related
nausea and vomiting and to reduce postoperative opioid administration. However, the …

Dexamethasone inhibits pancreatic tumor growth in preclinical models: Involvement of activating glucocorticoid receptor

Y Yao, Q Yao, J Xue, X Tian, Q An, L Cui, C Xu… - Toxicology and Applied …, 2020 - Elsevier
Glucocorticoid receptor (GR) modulates extensive biological and pathological processes
including tumor progression through diverse mechanisms. The regulatory effects of …

Effects of cortisone in zebrafish (Danio rerio): Insights into gut microbiota interactions and molecular mechanisms underlying DNA damage and apoptosis

J Tan, L Yang, M Ye, Y Geng, Y Guo, H Zou… - Journal of Hazardous …, 2024 - Elsevier
Cortisone can enter aquatic ecosystems and pose a risk to organisms therein. However, few
studies have explored the effects of cortisone on the gut microbiota of aquatic organisms …