Implementing central composite design for developing transdermal diacerein-loaded niosomes: ex vivo permeation and in vivo deposition

DE Aziz, AA Abdelbary, AI Elassasy - Current drug delivery, 2018 - ingentaconnect.com
Background: Niosomes are surfactant-based vesicular nanosystems that proved their
efficiency in transdermal delivery by overcoming skin inherent anatomic barrier; startum …

[PDF][PDF] Design-expert software (DOE): An application tool for optimization in pharmaceutical preparations formulation

I Sopyan, D Gozali, IS Kurniawansyah… - International Journal of …, 2022 - researchgate.net
Formulation is a crucial stage in drug development since it determines the best formula. The
quality of the preparation is good and fulfills the standard parameters when using the best …

Application of response surface methodology (RSM) in statistical optimization and pharmaceutical characterization of a patient compliance effervescent tablet …

APK Mahapatra, R Saraswat, M Botre, B Paul… - Future Journal of …, 2020 - Springer
Background The main objective of the present study was to develop and optimize an
effervescent tablet of levetiracetam, an antiepileptic drug, using central composite design …

Incorporating valsartan in sesame oil enriched self-nanoemulsifying system-loaded liquisolid tablets to improve its bioavailability

M Khalid, SH Alamri, HH Alsulimani, WS Alharbi… - International Journal of …, 2023 - Elsevier
Valsartan (VST) is a poorly soluble antihypertensive drug characterized by its limited
dissolution rate and low bioavailability. This study aims to improve VST solubility and …

Response surface method for optimization of prepared satranidazole powder layered pellets

R Mazumder, B Mahanti, S Majumdar, R Pal… - Future Journal of …, 2021 - Springer
Background The purpose of the present study was to evaluate layered of satranidazole
powder using natural polysaccharides as coating materials for colon targeting that were …

Development and characterisation of orally disintegrating flurbiprofen tablets using SeDeM-ODT tool

SS Fatima, F Zafar, H Ali, F Raees, GR Naqvi, S Alam… - Plos one, 2024 - journals.plos.org
In this study, SeDeM–ODT parametric tests were performed to determine the use of
ludipress as a directly compressible tableting excipient for the development of a flurbiprofen …

Investigating the penetrating potential of nanocomposite β-cycloethosomes: development using central composite design, in vitro and ex vivo characterization

N Akhtar, A Verma, K Pathak - Journal of liposome research, 2018 - Taylor & Francis
Context: Atopic dermatitis (AD) is a chronic skin disease characterized by inflammation of
the skin and has exhibited remarkable repercussions on human life across the globe …

[HTML][HTML] Model Adequacy in Assessing the Predictive Performance of Regression Models in Pharmaceutical Product Optimization: The Bedaquiline Solid Lipid …

CU Uche, MA Okezue, I Amidu, SR Byrn - Scientia Pharmaceutica, 2024 - mdpi.com
This study aimed to assess the predictive performance of first-and second-order regression
models in optimizing bedaquiline (BQ) solid lipid nanoparticle (SLN) formulations. A three …

Clinical pharmacokinetic evaluation of optimized liquisolid tablets as a potential therapy for male sexual dysfunction

FO Alotaibi, NA Alhakamy, AM Omar, KM El-Say - Pharmaceutics, 2020 - mdpi.com
The study aimed at developing a liquisolid tablet (LST) containing tadalafil (TDL) and
dapoxetine (DPX) with improved bioavailability as a potential therapy for male sexual …

Pharmacokinetics and bioequivalence assessment of optimized directly compressible Aceclofenac (100 mg) tablet formulation in healthy human subjects

R Bushra, MH Shoaib, H Ali, S Ghayas - Plos one, 2020 - journals.plos.org
The aim of the study was to determine the various pharmacokinetic parameters of the newly
developed cost-effective aceclofenac 100 mg tablet formulation (F-15) and to establish the …