CD9 tetraspanin: a new pathway for the regulation of inflammation?

C Brosseau, L Colas, A Magnan, S Brouard - Frontiers in immunology, 2018 - frontiersin.org
CD9 belongs to the tetraspanin superfamily. Depending on the cell type and associated
molecules, CD9 has a wide variety of biological activities such as cell adhesion, motility …

Tetraspanin assemblies in virus infection

L Florin, T Lang - Frontiers in immunology, 2018 - frontiersin.org
Tetraspanins (Tspans) are a family of four-span transmembrane proteins, known as plasma
membrane “master organizers.” They form Tspan-enriched microdomains (TEMs or TERMs) …

Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism

M Germain, DI Chasman, H De Haan, W Tang… - The American Journal of …, 2015 - cell.com
Venous thromboembolism (VTE), the third leading cause of cardiovascular mortality, is a
complex thrombotic disorder with environmental and genetic determinants. Although several …

Tetraspanin 4 stabilizes membrane swellings and facilitates their maturation into migrasomes

R Dharan, Y Huang, SK Cheppali, S Goren… - Nature …, 2023 - nature.com
Migrasomes are newly discovered cell organelles forming by local swelling of retraction
fibers. The migrasome formation critically depends on tetraspanin proteins present in the …

The origins of multicellular organisms

KJ Niklas, SA Newman - Evolution & development, 2013 - Wiley Online Library
Multicellularity has evolved in several eukaryotic lineages leading to plants, fungi, and
animals. Theoretically, in each case, this involved (1) cell‐to‐cell adhesion with an …

The evolutionary‐developmental origins of multicellularity

KJ Niklas - American journal of botany, 2014 - Wiley Online Library
Multicellularity has evolved at least once in every major eukaryotic clade (in all ploidy levels)
and numerous times among the prokaryotes. According to a standard multilevel selection …

Transmembrane proteins tetraspanin 4 and CD9 sense membrane curvature

R Dharan, S Goren, SK Cheppali… - Proceedings of the …, 2022 - National Acad Sciences
Multiple membrane-shaping and remodeling processes are associated with tetraspanin
proteins by yet unknown mechanisms. Tetraspanins constitute a family of proteins with four …

Tetraspanin CD151 mediates papillomavirus type 16 endocytosis

KD Scheffer, A Gawlitza, GA Spoden, XA Zhang… - Journal of …, 2013 - Am Soc Microbiol
ABSTRACT Human papillomavirus type 16 (HPV16) is the primary etiologic agent for
cervical cancer. The infectious entry of HPV16 into cells occurs via a so-far poorly …

Natural products against cancer angiogenesis

EB Khalid, ELMELK Ayman, H Rahman, G Abdelkarim… - Tumor Biology, 2016 - Springer
The process of angiogenesis is quite well-known nowadays. Some medicines and extracts
affecting this process are already used routinely in supporting the conventional treatment of …

Structure and function of Norrin in assembly and activation of a Frizzled 4–Lrp5/6 complex

J Ke, KG Harikumar, C Erice, C Chen, X Gu… - Genes & …, 2013 - genesdev.cshlp.org
Norrin is a cysteine-rich growth factor that is required for angiogenesis in the eye, ear, brain,
and female reproductive organs. It functions as an atypical Wnt ligand by specifically binding …