Modern vaccine design has sought a minimalization approach, moving to the isolation of
antigens from pathogens that invoke a strong neutralizing immune response. This approach …

Influenza A virus causes seasonal epidemics, sporadic pandemics and is a significant
global health burden. Influenza virus is an enveloped virus that contains a segmented …

The influenza A virus genome consists of eight single-stranded negative-sense RNA (vRNA)
segments. Although genome segmentation provides advantages such as genetic …

In the extracellular environment, cell-free virions seek out naive host cells over long
distances and between organisms. This is the primary mechanism of spread for most …

Assembly and budding of influenza virus proceeds in the viral budozone, a domain in the
plasma membrane with characteristics of cholesterol/sphingolipid‐rich membrane rafts. The …

The assembly of influenza A virus at the plasma membrane of infected cells leads to release
of enveloped virions that are typically round in tissue culture-adapted strains but filamentous …

The M1 of influenza A virus (IAV) is important for the virus life cycle, especially for the
assembly and budding of viruses, which is a multistep process that requires host factors …

The outbreak of coronavirus disease 2019 (COVID-19) caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has shaken the global health system …

The matrix protein M1 plays a pivotal role in the budding of influenza virus from the plasma
membrane (PM) of infected cells. This protein interacts with viral genetic material and …

We have determined that, in addition to its receptor-destroying activity, the influenza virus
neuraminidase is capable of efficiently forming virus-like particles (VLPs) when expressed …