Radiation therapy (RT) plays a key role in curative-intent treatments for head and neck
cancers. Its use is indicated as a sole therapy in early stage tumors or in combination with …

Squamous cell carcinoma of the head and neck (SCCHN) is among the most prevalent
cancer types worldwide. Despite multimodal therapeutic approaches that include surgical …

Image features need to be robust against differences in positioning, acquisition and
segmentation to ensure reproducibility. Radiomic models that only include robust features …

The key goal and main challenge of radiation therapy is the elimination of tumors without
any concurring damages of the surrounding healthy tissues and organs. Radiation doses …

Background and purpose Tumor hypoxia is a major cause of resistance to
radiochemotherapy in locally advanced head-and-neck cancer (LASCCHN). We present …

The progressive integration of positron emission tomography/computed tomography
(PET/CT) imaging in radiation therapy has its rationale in the biological intertumoral and …

The pace of technological innovation over the past three decades has transformed the field
of radiotherapy into one of the most technologically intense disciplines in medicine …

Over the last decades, the incidence of human papilloma virus (HPV) positive head and
neck squamous-cell carcinoma (HNSCC) has significantly increased. Infection with high-risk …

Hypoxia in solid tumors is thought to be an important factor in resistance to therapy, but the
extreme microscopic heterogeneity of the partial pressures of oxygen (pO2) between the …

Simple Summary HPV-related oropharyngeal squamous cell carcinoma patients have a very
good prognosis but are often suffering from long-term treatment-induced toxicities …