Crystallization is a fundamental separation technology used for the production of particulate
solids. Accurate nucleation and growth process control are vitally important but difficult. A …

Measuring the solution concentration of processes for product quality control in industrial
crystallization processes is a hot topic. In recent years, with the development of process …

This work considers a seeded fesoterodine fumarate (FF) cooling crystallization and
presents the methodology and implementation of a real‐time machine learning modeling …

Nucleation as a unique phenomenon in the crystallization process has always been a hot
topic. With the development of nucleation theory and process analysis technology (PAT) …

The release of the FDA's guidance on Process Analytical Technology has motivated and
supported the pharmaceutical industry to deliver consistent quality medicine by acquiring a …

To deal with the typically insufficiently labeled samples involved in practical spectroscopy
measurements, a conditional variational autoencoder (CVAE) is proposed to guide the …

This work presents a proposal for the indirect monitoring of cane sugar crystallization using
the multiscale analysis of temperature, pH, and torque time series. The time series were …

In this paper, a seed recipe design is proposed for batch cooling crystallization to obtain the
desired product attributes including product yield and product size distribution, based on …

Multivariate models have been widely used in analytical problems involving quantitative and
qualitative analyzes. However, there are cases in which a model is not applicable to spectra …

For using infrared spectroscopy to conduct in-situ measurement of slurry component
concentrations during batch crystallization or fermentation process in engineering practice, a …