METHODS Search Strategy A research librarian (RLH) developed and conducted searches
after consulting with the systematic review team. Searches were developed for PubMed …

Abstract Purpose of Review Coagulopathy is a complex pathological condition manifested
through the insufficient or excessive tendency to form blood thrombi, which can be caused …

Thrombin generation (TG) and fibrin clot formation represent the central process of blood
coagulation. Up to 95% of thrombin is considered to be generated after the clot is formed …

Thrombin generation (TG) assays are used widely to investigate both diseases and drugs
that impact thrombosis and bleeding. TG assays were also instrumental in the identification …

Perioperative management of cardiovascular surgical procedures requiring
cardiopulmonary bypass (CPB) in patients with hemophilia A poses a clinical challenge in …

Introduction The thrombin generation test (TGT) is used both as a global haemostasis assay,
and to compare activities of coagulation factor concentrates that have been spiked into …

Background Cardiac surgery poses a significant risk of perioperative bleeding and
allogeneic blood transfusions, particularly in patients with bleeding disorders. Increasingly …

Abstract Background/Objective While four‐factor prothrombin complex concentrate (4F‐
PCC) is FDA‐approved for reversal of warfarin‐induced major bleeding, its use in real‐world …

Background Prothrombin complex concentrate (PCC) is increasingly used to correct
acquired coagulopathy in trauma and surgery. Dosing of PCC is guided by the prothrombin …

This study aimed to characterize the utilization of four-factor prothrombin complex
concentrate (4F-PCC) at a tertiary academic medical center and evaluate the incidence of …