Regulated cell death mediated by dedicated molecular machines, known as programmed
cell death, plays important roles in health and disease. Apoptosis, necroptosis and …

Cell suicide pathways, termed regulated cell death (RCD), play a critical role in organismal
development, homeostasis, and pathogenesis. Here, we provide an overview of key RCD …

Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide. Motor deficits usually associated with PD correlate with dopaminergic axonal …

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

Active cell death, in its many forms, is a fundamental biological process. Studies over the
past several decades have explored the functions and consequences of cellular demise and …

Inflammaging, characterized by an increase in low‐grade chronic inflammation with age, is a
hallmark of aging and is strongly associated with various age‐related diseases, including …

Dying cells have an important role in the initiation of CD8+ T cell-mediated immunity. The
cross-presentation of antigens derived from dying cells enables dendritic cells to present …

Necroptosis, a form of regulated necrotic cell death mediated by RIPK1 (receptor-interacting
protein kinase 1) kinase activity, RIPK3, and MLKL (mixed-lineage kinase domain-like …

Necroptosis is a form of regulated cell death, which is induced by ligand binding to TNF
family death domain receptors, pattern recognizing receptors and virus sensors. The …

The coevolution of host-pathogen interactions underlies many human physiological traits
associated with protection from or susceptibility to infections. Among the mechanisms that …