Leucettinibs, a Class of DYRK/CLK Kinase Inhibitors Inspired by the Marine Sponge Natural Product Leucettamine B
E Deau, MF Lindberg, F Miege, D Roche… - Journal of Medicinal …, 2023 - ACS Publications
Dual-specificity, tyrosine phosphorylation-regulated kinases (DYRKs) and cdc2-like kinases
(CLKs) recently attracted attention due to their central involvement in various pathologies …
(CLKs) recently attracted attention due to their central involvement in various pathologies …
On a path toward a broad-spectrum anti-viral: inhibition of HIV-1 and coronavirus replication by SR kinase inhibitor harmine
ABSTRACT RNA processing plays a key role in gene expression, allowing for increased
protein diversity and functional complexity. Consequently, modulating RNA processing can …
protein diversity and functional complexity. Consequently, modulating RNA processing can …
Serine-arginine protein kinases and their targets in viral infection and their inhibition
K Zheng, Z Ren, Y Wang - Cellular and Molecular Life Sciences, 2023 - Springer
Accumulating evidence has consolidated the interaction between viral infection and host
alternative splicing. Serine-arginine (SR) proteins are a class of highly conserved splicing …
alternative splicing. Serine-arginine (SR) proteins are a class of highly conserved splicing …
A Canadian Survey of Research on HIV-1 Latency—Where Are We Now and Where Are We Heading?
AL Abdalla, G Guajardo-Contreras, AJ Mouland - Viruses, 2024 - mdpi.com
Worldwide, almost 40 million people are currently living with HIV-1. The implementation of
cART inhibits HIV-1 replication and reduces viremia but fails to eliminate HIV-1 from latently …
cART inhibits HIV-1 replication and reduces viremia but fails to eliminate HIV-1 from latently …
Discovery of novel 5-methoxybenzothiophene hydrazides as metabolically stable Clk1 inhibitors with high potency and unprecedented Clk1 isoenzyme selectivity
Clk1 kinase is a key modulator of the pre-mRNA alternative splicing machinery which has
been proposed as a promising target for treatment of various tumour types, Duchenne's …
been proposed as a promising target for treatment of various tumour types, Duchenne's …
Regulatory interplay between SR proteins governs CLK1 kinase splice variants production
The CLK1 kinase phosphorylates SR proteins to modulate their splicing regulatory activity.
Skipping of alternative exon 4 on the CLK1 pre-mRNA produces a CLK1 variant lacking the …
Skipping of alternative exon 4 on the CLK1 pre-mRNA produces a CLK1 variant lacking the …
[HTML][HTML] The anticancer potential of the CLK kinases inhibitors 1C8 and GPS167 revealed by their impact on the epithelial-mesenchymal transition and the antiviral …
L Shkreta, J Toutant, A Delannoy, D Durantel… - Oncotarget, 2024 - ncbi.nlm.nih.gov
The diheteroarylamide-based compound 1C8 and the aminothiazole carboxamide-related
compound GPS167 inhibit the CLK kinases, and affect the proliferation of a broad range of …
compound GPS167 inhibit the CLK kinases, and affect the proliferation of a broad range of …
[HTML][HTML] Exploiting the Achilles' Heel of Viral RNA Processing to Develop Novel Antivirals
Treatment options for viral infections are limited and viruses have proven adept at evolving
resistance to many existing therapies, highlighting a significant vulnerability in our defenses …
resistance to many existing therapies, highlighting a significant vulnerability in our defenses …
Interferon-Regulated Expression of Cellular Splicing Factors Modulates Multiple Levels of HIV-1 Gene Expression and Replication
F Roesmann, L Müller, K Klaassen, S Heß, M Widera - Viruses, 2024 - mdpi.com
Type I interferons (IFN-Is) are pivotal in innate immunity against human immunodeficiency
virus I (HIV-1) by eliciting the expression of IFN-stimulated genes (ISGs), which encompass …
virus I (HIV-1) by eliciting the expression of IFN-stimulated genes (ISGs), which encompass …
[HTML][HTML] Identification of tyrphostin AG879 and A9 inhibiting replication of Chikungunya virus by screening of a kinase inhibitor library
Y He, Z Pan, Y Liu, L Jiang, H Peng, P Zhao, Z Qi, Y Liu… - Virology, 2023 - Elsevier
Chikungunya virus (CHIKV) is a globally public health threat. There are currently no
medications available to treat CHIKV infection. High-throughput screening of 419 kinase …
medications available to treat CHIKV infection. High-throughput screening of 419 kinase …